SCHEMBL8465837

SCHEMBL8465837

CCn1ccnc1SCCC=C(F)F

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.32
ALDH1A1 P00352 2/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
HPGD P15428 2/20 0.32
POLB P06746 2/20 0.32
HTT P42858 1/20 0.32
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
TP53 P04637 2/20 0.31
MAPT P10636 1/20 0.31
CHRM5 P08912 1/20 0.30
CHRM1 P11229 1/20 0.30
GFER P55789 1/20 0.30
CYP1A2 P05177 2/20 0.30
CYP3A4 P08684 2/20 0.30
CYP2D6 P10635 2/20 0.30
CYP2C9 P11712 2/20 0.30
CYP2C19 P33261 2/20 0.30
ALOX12 P18054 1/20 0.30
NPC1 O15118 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8465617 0.89 ALDH1A1 (0.33) LMNAALDH1A1SMN1; SMN2HPGDPOLB
SCHEMBL8467079 0.87 ALDH1A1 (0.33) LMNAALDH1A1SMN1; SMN2HPGDMEN1
SCHEMBL8465429 0.82 KDM4E (0.44) ALDH1A1SMN1; SMN2HPGDPOLBMEN1
SCHEMBL8463515 0.78
SCHEMBL8465849 0.76 KDM4E (0.34) ALDH1A1SMN1; SMN2MEN1KMT2ARAB9A
SCHEMBL8466866 0.73 L3MBTL1 (0.62) LMNAALDH1A1SMN1; SMN2POLBMEN1
SCHEMBL8463260 0.72 LMNA (0.34) LMNAALDH1A1
SCHEMBL7350391 0.69 KMT2A (0.39) LMNAALDH1A1SMN1; SMN2HPGDPOLB
SCHEMBL8463544 0.69 MEN1 (0.33) LMNAALDH1A1SMN1; SMN2MEN1KMT2A
SCHEMBL8466811 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5952359-A NEMATICIDES, INSECTICIDES AND MITICIDES; 1,1-DIFLUORO-3-(THIAZOLYL OR ISOTHIAZOYL-THIO (OR SULFINYL OR SULFONYL)-PROP-1-ENE DERIVATIVES ZENECA LIMITED (GB) 1999-09-14 US disclosed
US-5912243-A NOVEL COMPOUNDS FOR CONTROLLING NEMATODES, INSECT OR ACARID PESTS ZENECA LIMITED (GB) 1999-06-15 US disclosed
US-5705516-A NEMATOCIDES, INSECTICIDES, ACARICIDES ZENECA LIMITED (GB) 1998-01-06 US disclosed
WO-1995024403-A1 (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY ZENECA LIMITED (GB) 1995-09-14 WO disclosed