Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.31 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8468051 | 0.80 | NISCH (0.32) | NISCH | |
| Hydrochloric Acid SCHEMBL8468727 | 0.78 | PDE4B (0.31) | — | |
| SCHEMBL27380339 | 0.77 | NPC1 (0.36) | NISCHNPC1CASP3RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8466558 | 0.70 | CYP2D6 (0.34) | NISCHACHE | |
| Hydrochloric Acid SCHEMBL7566924 | 0.68 | NISCH (0.35) | NISCHNPC1CASP3RAB9ASMN1; SMN2 | |
| SCHEMBL17393756 | 0.65 | TSHR (0.45) | NISCHNPC1CASP3RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4461337 | 0.63 | — | — | |
| Hydrochloric Acid SCHEMBL5608731 | 0.63 | CALM1 (0.37) | RAB9ATSHRALDH1A1 | |
| SCHEMBL79391 | 0.63 | ALDH1A1 (0.44) | NPC1RAB9ASMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL197690 | 0.63 | ACHE (0.64) | NISCHNPC1CASP3RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5973083-A | HIGH IMPACT RESISTANCE AND HIGH STIFFNESS, EXCELLENT MOLDABILITY, HIGH MELT FLOWABILITY | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1999-10-26 | — | — | US | disclosed |
| EP-0776909-A1 | HIGH-DENSITY ETHYLENIC POLYMER AND PROCESS FOR PRODUCING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1997-06-04 | — | — | EP | disclosed |