Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321803 | 0.91 | HDAC8 (0.41) | MAPTTP53GAAHDAC8KMT2A | |
| SCHEMBL8663363 | 0.84 | MAPT (0.51) | MAPTTP53ALDH1A1KDM4EKMT2A | |
| SCHEMBL8462423 | 0.78 | MAPT (0.47) | MAPTTP53ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL8666469 | 0.78 | MAPT (0.44) | MAPTTP53GAAHDAC8ALDH1A1 | |
| SCHEMBL8664948 | 0.78 | TP53 (0.48) | MAPTTP53GAAALDH1A1KMT2A | |
| SCHEMBL29943980 | 0.75 | ADORA1 (0.45) | MAPTGAAALDH1A1KDM4EKMT2A | |
| SCHEMBL8662409 | 0.74 | MAPT (0.54) | MAPTTP53ALDH1A1KDM4EKMT2A | |
| SCHEMBL12814098 | 0.74 | NPSR1 (0.55) | MAPTGAAALDH1A1KDM4EKMT2A | |
| SCHEMBL7351054 | 0.74 | SMN1; SMN2 (0.50) | MAPTGAAHDAC8ALDH1A1KDM4E | |
| SCHEMBL8259577 | 0.74 | TSHR (0.52) | MAPTGAAL3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912175-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1999-09-08 | — | — | EP | disclosed |
| EP-0912175-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1999-05-06 | — | — | EP | disclosed |
| US-5854245-A | Fibrinogen receptor antagonists | MERCK & CO., INC. (US) | 1998-12-29 | — | — | US | disclosed |
| WO-1998000134-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-01-08 | — | — | WO | disclosed |