SCHEMBL8468859

SCHEMBL8468859

FC(F)(F)c1c2nc(cc3ccc([nH]3)c(C(F)(F)F)c3nc(cc4ccc1[nH]4)C=C3)C=C2

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ STAT3 P40763 1/20 0.49
▸ STAT1 P42224 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8466680 0.95 STAT3 (0.44) STAT3STAT1
SCHEMBL28533125 0.89 STAT3 (0.41) STAT3STAT1
SCHEMBL8473510 0.85 STAT3 (0.45) STAT3STAT1
SCHEMBL6747972 0.83 STAT3 (0.43) STAT3STAT1
SCHEMBL4585422 0.81 STAT3 (0.47) STAT3STAT1
SCHEMBL28535234 0.81 STAT3 (0.36) STAT3STAT1
SCHEMBL8001501 0.79 TERT (0.37) —
SCHEMBL8466676 0.78 STAT3 (0.36) STAT3STAT1
SCHEMBL51570 0.78 STAT3 (0.59) STAT3STAT1
SCHEMBL8677261 0.77 STAT3 (0.37) STAT3STAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240083920-A1 LOW MOLECULAR WEIGHT CORROLE COMPOSITIONS TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD (IL) 2024-03-14 — — US disclosed
EP-4277906-A1 LOW MOLECULAR WEIGHT CORROLE COMPOSITIONS Technion Research & Development Foundation Ltd. (IL) 2023-11-22 — — EP disclosed
WO-2022153294-A1 LOW MOLECULAR WEIGHT CORROLE COMPOSITIONS TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD (IL) 2022-07-21 — — WO disclosed
US-10450322-B2 Low molecular weight derivatives of carboxamide halogenated porphyrins, namely chlorins and bacteriochlorins, and their applications thereof LUZITIN, S.A. (PT) 2019-10-22 — — US disclosed
EP-3292129-B1 LOW MOLECULAR WEIGHT HALOGENATED PORPHYRINE CARBOXAMIDE CHLORIN AND BACTERIOCHLORIN DERIVATIVES FOR USE IN PHOTODYNAMIC THERAPY FOR TREATING CANCER LUZITIN S A (PT) 2019-03-27 — — EP disclosed
US-20180282344-A1 LOW MOLECULAR WEIGHT DERIVATIVES OF CARBOXAMIDE HALOGENATED PORPHYRINS, NAMELY CHLORINS AND BACTERIOCHLORINS, AND THEIR APPLICATIONS THEREOF LUZITIN, S.A. (PT) 2018-10-04 — — US disclosed
US-5990363-A Method for oxidizing alkanes using novel porphyrins synthesized from dipyrromethanes and aldehydes SUN COMPANY, INC. (US) 1999-11-23 — — US disclosed
US-5760217-A Porphyrins and their synthesis from dipyrromethanes and aldehydes SUN COMPANY, INC. (US) 1998-06-02 — — US disclosed
US-5723677-A Method for hydroperoxide decomposition using novel porphyrins synthesized from dipyrromethanes and aldehydes SUN COMPANY, INC. (R&M) (US) 1998-03-03 — — US disclosed
US-5571908-A Porphyrins SUN COMPANY, INC. (R&M) (US) 1996-11-05 — — US disclosed
EP-0665056-A2 Method for oxidizing alkanes using halocarbyl-substituted porphyrins synthesized from meso-halocarbyl-dipyrromethanes and aldehydes SUN COMPANY, INC. (R&M) (US) 1995-08-02 — — EP disclosed
EP-0665230-A2 Halocarbyl-substituted porphyrins and their synthesis from meso-halocarbyl-dipyrromethanes and aldehydes SUN COMPANY, INC. (R&M) (US) 1995-08-02 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10450322-B2 Low molecular weight derivatives of carboxamide halogenated porphyrins, namely chlorins and bacteriochlorins, and their applications thereof CRY1, PPIA, PPOX STAT3 361/4885STAT1 833/4885
US-20180282344-A1 LOW MOLECULAR WEIGHT DERIVATIVES OF CARBOXAMIDE HALOGENATED PORPHYRINS, NAMELY CHLORINS AND BACTERIOCHLORINS, AND THEIR APPLICATIONS THEREOF CRY1, PPIA, PPOX STAT3 361/4885STAT1 833/4885
US-20240083920-A1 LOW MOLECULAR WEIGHT CORROLE COMPOSITIONS CA13, CA11, IGFBP3 STAT3 2579/4885STAT1 4091/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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