Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | STK10 | O94804 | 2/20 | 0.43 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | C1R | P00736 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8468841 | 0.80 | ALOX5 (0.53) | MAPTALDH1A1RAB9ASMN1; SMN2GPR84 | |
| SCHEMBL28108979 | 0.75 | MAPT (0.55) | MAPTALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL28662170 | 0.72 | ALDH1A1 (0.52) | MAPTALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL13027936 | 0.70 | AURKA (0.50) | MAPTALDH1A1MEN1KMT2AAURKA | |
| SCHEMBL26140521 | 0.69 | GPR84 (0.49) | MAPTALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL31069613 | 0.68 | AURKA (0.47) | ALDH1A1AURKAKDRCA12CA9 | |
| SCHEMBL18858106 | 0.68 | NQO1 (0.57) | MAPTALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL9834200 | 0.68 | MAP3K9 (0.58) | KDRPARP1 | |
| SCHEMBL21615640 | 0.67 | GPR84 (0.57) | MAPTALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL11043607 | 0.67 | MAPT (0.62) | MAPTALDH1A1MEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920416-A1 | NAPHTHOLACTAMS AND LACTONES AS BONE MORPHOGENETIC PROTEIN ACTIVE AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998007705-A1 | NAPHTHOLACTAMS AND LACTONES AS BONE MORPHOGENETIC PROTEIN ACTIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-26 | — | — | WO | disclosed |