Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.46 |
| ▸ | AURKA | O14965 | 3/20 | 0.45 |
| ▸ | PLK4 | O00444 | 2/20 | 0.45 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | CCND1 | P24385 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | XRCC6 | P12956 | 1/20 | 0.44 |
| ▸ | XRCC5 | P13010 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8466568 | 0.82 | KDR (0.44) | ALOX5KDRAURKAPLK4NUAK1 | |
| SCHEMBL8469010 | 0.80 | MAPT (0.45) | ALDH1A1SMN1; SMN2HPGDKDM4EMAPT | |
| SCHEMBL26506265 | 0.79 | ABCG2 (0.47) | ALOX5ALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL29847407 | 0.75 | ALOX5 (0.58) | ALOX5ALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL18762062 | 0.75 | ALOX5 (0.58) | ALOX5ALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL12873375 | 0.71 | ALOX5 (0.55) | ALOX5ALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL18270053 | 0.71 | GPR84 (0.51) | ALOX5ALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL27712556 | 0.70 | ALOX5 (0.53) | ALOX5ALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL9612396 | 0.70 | ALOX5 (0.49) | ALOX5ALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL8072870 | 0.69 | ALOX5 (0.55) | ALOX5ALDH1A1SMN1; SMN2HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920416-A1 | NAPHTHOLACTAMS AND LACTONES AS BONE MORPHOGENETIC PROTEIN ACTIVE AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998007705-A1 | NAPHTHOLACTAMS AND LACTONES AS BONE MORPHOGENETIC PROTEIN ACTIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-26 | — | — | WO | disclosed |