SCHEMBL8469727

SCHEMBL8469727

O=C(O)c1ccc2c(c1)CN=NO2

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.46
ALDH1A1 P00352 5/20 0.46
MAPK1 P28482 2/20 0.46
SRD5A2 P31213 5/20 0.39
SRD5A1 P18405 3/20 0.39
RXRA P19793 1/20 0.37
KDM4E B2RXH2 5/20 0.37
MAPT P10636 4/20 0.37
CA12 O43570 2/20 0.37
CA1 P00915 2/20 0.37
CA2 P00918 2/20 0.37
CA4 P22748 2/20 0.37
CA9 Q16790 2/20 0.37
ALOX5 P09917 1/20 0.36
POLB P06746 2/20 0.36
GAA P10253 2/20 0.36
CA6 P23280 1/20 0.36
PTGS2 P35354 1/20 0.36
CA7 P43166 1/20 0.36
CA14 Q9ULX7 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3712693 0.73 TDP1 (0.46) TDP1ALDH1A1MAPK1SRD5A2SRD5A1
Hydrochloric Acid SCHEMBL10700892 0.72 TDP1 (0.45) TDP1ALDH1A1MAPK1SRD5A2SRD5A1
SCHEMBL11751146 0.69 ALDH1A1 (0.53) TDP1ALDH1A1MAPK1SRD5A2SRD5A1
SCHEMBL578233 0.67 ALDH1A1 (0.57) TDP1ALDH1A1MAPK1SRD5A2SRD5A1
SCHEMBL3862277 0.67 ALDH1A1 (0.50) TDP1ALDH1A1MAPK1SRD5A2SRD5A1
SCHEMBL1395976 0.67 PRKCI (0.64) TDP1ALDH1A1MAPK1SRD5A2SRD5A1
Hydrochloric Acid SCHEMBL4894045 0.66 PRKCI (0.62) TDP1ALDH1A1MAPK1SRD5A2SRD5A1
SCHEMBL14999027 0.66 MAOA (0.56) TDP1ALDH1A1MAPK1SRD5A2SRD5A1
SCHEMBL5395777 0.64 TDP1 (0.47) TDP1ALDH1A1MAPK1SRD5A2SRD5A1
SCHEMBL31262479 0.64 CTNNB1 (0.67) TDP1ALDH1A1MAPK1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114249749-A Conversion method of marbofloxacin formate 天象生物药业邢台有限责任公司 2022-03-29 CN disclosed
US-5892040-A Process for the manufacture of a tricyclic compound PFIZER. INC (US) 1999-04-06 US disclosed
US-5783708-A HEXAHYDROISOINDOLE DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 1998-07-21 US disclosed
US-5753669-A BACTERICIDES BAYER AKTIENGESELLSCHAFT (DE) 1998-05-19 US disclosed
US-5703094-A Quinolone- and naphthyridonecarboxylic acid derivatives BAYER AKTIENGESELLSCHAFT (DE) 1997-12-30 US disclosed
US-5679675-A BACTERICIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-10-21 US disclosed
US-5679689-A BACTERICIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-10-21 US disclosed