Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.36 |
| ▸ | GAA known ✓ | P10253 | 2/20 | 0.35 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 5/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712693 | 0.98 | TDP1 (0.46) | TDP1ALDH1A1MAPK1SRD5A2SRD5A1 | |
| SCHEMBL19207342 | 0.85 | ALDH1A1 (0.46) | TDP1ALDH1A1MAPK1SRD5A2SRD5A1 | |
| SCHEMBL10509462 | 0.84 | NPC1 (0.46) | TDP1KDM4EMAPTPOLBMEN1 | |
| SCHEMBL9995987 | 0.84 | TSHR (0.47) | ALDH1A1KDM4ETSHRRAB9A | |
| SCHEMBL8469727 | 0.72 | TDP1 (0.46) | TDP1ALDH1A1MAPK1SRD5A2SRD5A1 | |
| SCHEMBL7502955 | 0.72 | RAB9A (0.41) | TDP1ALDH1A1MAPK1POLBMEN1 | |
| SCHEMBL5586035 | 0.71 | TSHR (0.47) | ALDH1A1MAPK1KDM4ETSHRRAB9A | |
| SCHEMBL5395777 | 0.70 | TDP1 (0.47) | TDP1ALDH1A1MAPK1SRD5A2SRD5A1 | |
| Carbamic Acid SCHEMBL6649969 | 0.70 | HSD17B10 (0.34) | TDP1ALDH1A1MAPK1KDM4EMAPT | |
| SCHEMBL3199131 | 0.69 | ALDH1A1 (0.47) | TDP1ALDH1A1MAPK1SRD5A2SRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101792452-B | Preparation method of high-purity antofloxacin hydrochloride | ANHUI GLOBE PHARMACEUTICAL CO LTD | 2011-06-08 | — | — | CN | disclosed |
| CN-101812074-A | Method for preparing antofloxacin hydrochloride | ANHUI GLOBE PHARMACEUTICAL CO LTD | 2010-08-25 | — | — | CN | disclosed |
| CN-101792452-A | Preparation method of high-purity antofloxacin hydrochloride | ANHUI GLOBE PHARMACEUTICAL CO LTD | 2010-08-04 | — | — | CN | disclosed |
| CN-1778800-A | Chiral piperazine substrated quinolone carboxylic acid derivative, and preparation and use thereof | SHANGHAI PHARMACEUTIC INST CHI (CN) | 2006-05-31 | — | — | CN | disclosed |
| CN-1256328-C | Position seven substituted amine methyl fluoro quinolone derivative having antibacterial activity and its preparation method | SHANGHAI INST PHARM INDUSTRY (CN) | 2006-05-17 | — | — | CN | disclosed |
| CN-1653071-A | 10-(3-cyclopropylaminomethyl-1-pyrrolidinyl)pyridobenzoxazinecarboxylic acid derivative effective against resistant bacterium | KYORIN SEIYAKU KK (JP) | 2005-08-10 | — | — | CN | disclosed |
| CN-1566117-A | Fluorine quinolone compounds and synthetic method thereof | BEIJING DOUBLE CRANE PHARMACEU (CN) | 2005-01-19 | — | — | CN | disclosed |
| CN-1493562-A | Position seven substituted amine methyl fluoro quinolone derivative having antibacterial activity and its preparation method | 上海医药工业研究院 | 2004-05-05 | — | — | CN | disclosed |
| CN-1042732-C | Antimicrobial agent for animals | DAIICHI SEIYAKU CO (JP) | 1999-03-31 | — | — | CN | disclosed |
| CN-1079745-A | New 9-fluoro-7-oxo-7H-pyrido [1,2,3-d, e] [1,4] benzoxazine-6-carboxylic acids and ester thereof | BAYER AG (DE) | 1993-12-22 | — | — | CN | disclosed |
| CN-1079744-A | 7-oxo-7H-pyrido [1,2,3 ,-d, e] [1,4] benzoxazine-6-carboxylic acids and ester thereof | BAYER AG (DE) | 1993-12-22 | — | — | CN | disclosed |
| CN-1040200-A | ANTIMICROBIAL AGENT FOR ANIMALS | DAIICHI SEIYAKU CO (JP) | 1990-03-07 | — | — | CN | disclosed |
| EP-0265230-A1 | Substituted-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acids, derivatives thereof, pharmaceutical compositions comprising the compounds, and processes for producing the compounds | WARNER-LAMBERT COMPANY (US) | 1988-04-27 | — | — | EP | disclosed |
| CN-86104479-A | The preparation method of pyridone carboxylic acid derivatives | — | 1987-02-04 | — | — | CN | disclosed |