Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.57 |
| ▸ | DRD2 | P14416 | 5/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 3/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8664537 | 0.97 | DRD2 (0.57) | ACHEDRD2SLC6A4HTR2A | |
| SCHEMBL1545276 | 0.95 | ACHE (0.59) | ACHEDRD2SLC6A4HTR2AHTR1A | |
| SCHEMBL7744954 | 0.84 | DRD2 (0.52) | ACHEDRD2SLC6A4HTR2AHTR1A | |
| SCHEMBL1545853 | 0.83 | ACHE (0.60) | ACHEDRD2SLC6A4HTR2AHTR1A | |
| Hydrochloric Acid SCHEMBL8627510 | 0.82 | ACHE (0.56) | ACHEDRD2SLC6A4HTR2A | |
| SCHEMBL8788161 | 0.80 | DRD2 (0.40) | ACHEDRD2SLC6A4HTR2AHTR1A | |
| SCHEMBL6644402 | 0.80 | PARP1 (0.49) | DRD2SLC6A4HTR2AHTR1A | |
| SCHEMBL793140 | 0.78 | DRD2 (0.70) | ACHEDRD2SLC6A4HTR2AHTR1A | |
| SCHEMBL791048 | 0.78 | DRD2 (0.70) | ACHEDRD2SLC6A4HTR2AHTR1A | |
| SCHEMBL28972648 | 0.78 | DRD2 (0.60) | ACHEDRD2SLC6A4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889035-A | 1-(Arylthioalkyl, arylaminoalkyl or arylmethylenealkyl)-3-(heteroaryl) pyrrolidines and related compounds useful as antipsychotics and analgesics | HOECHST MARION ROUSSEL, INC. (US) | 1999-03-30 | — | — | US | disclosed |
| US-5874435-A | PSYCHOLOGICAL DISORDERS; ANALGESICS | HOECHST MARION ROUSSEL, INC. (US) | 1999-02-23 | — | — | US | disclosed |
| US-5854243-A | 3-heteroaryl-1-pyrrolidinealkylthiols and derivatives thereof and their therapeutic utility | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1998-12-29 | — | — | US | disclosed |
| US-5843977-A | (3-heteroaryl-1-pyrrolidinyl) alkoxy!-3,4-dihydro-1(2H)-naphthalenones and related compounds and their therapeutic utility | HOECHST MARION ROSUEEL, INC. | 1998-12-01 | — | — | US | disclosed |
| US-5840727-A | ANTIPSYCHOTICS, ANALGESICS | AVENTIS PHARMACEUTICALS INC. | 1998-11-24 | — | — | US | disclosed |
| US-5811435-A | 2- (4-heteroaryl-1-piperidinyl)alkyl!-1,3-dioxanes and related compounds and their therapeutic utility | HOECHST MARION RUSSEL, INC. | 1998-09-22 | — | — | US | disclosed |