Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 8/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD5 | P21918 | 2/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | HTR1B | P28222 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8789450 | 0.86 | DRD2 (0.42) | DRD2ACHEHTR2AHTR1ASLC6A4 | |
| SCHEMBL1545276 | 0.85 | ACHE (0.59) | DRD2ACHEHTR2AHTR1ASLC6A4 | |
| SCHEMBL8469854 | 0.80 | ACHE (0.57) | DRD2ACHEHTR2AHTR1ASLC6A4 | |
| SCHEMBL8664537 | 0.79 | DRD2 (0.57) | DRD2ACHEHTR2ASLC6A4HTR6 | |
| SCHEMBL8787429 | 0.78 | DRD2 (0.47) | DRD2ACHEHTR2AHTR1ASLC6A4 | |
| Hydrochloric Acid SCHEMBL8787530 | 0.78 | DRD2 (0.46) | DRD2ACHEHTR2AHTR1ASLC6A4 | |
| SCHEMBL8787558 | 0.77 | DRD2 (0.49) | DRD2HTR2AHTR1AKCNH2 | |
| SCHEMBL8788723 | 0.77 | DRD2 (0.49) | DRD2HTR2AHTR1ASLC6A4HTR2C | |
| SCHEMBL8789443 | 0.76 | ACHE (0.46) | DRD2ACHEHTR2AHTR1ASLC6A4 | |
| SCHEMBL8788393 | 0.75 | DRD2 (0.43) | DRD2ACHEHTR2AHTR1AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730452-A4 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST ROUSSEL PHARMA (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0730452-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST MARION ROUSSEL, Inc. (US) | 1996-09-11 | — | — | EP | disclosed |