Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8470458 | 0.76 | SLC6A2 (0.36) | SLC6A2SLC6A4PGRDRD2DRD3 | |
| SCHEMBL6909258 | 0.65 | PGR (0.57) | SLC6A2SLC6A4PGRADORA3ADORA2A | |
| SCHEMBL7085096 | 0.65 | POLB (0.44) | SLC6A2SLC6A4ADORA3DRD2DRD3 | |
| SCHEMBL8407506 | 0.63 | KDM4E (0.49) | DRD2 | |
| SCHEMBL6335458 | 0.62 | TACR1 (0.55) | — | |
| Hydrochloric Acid SCHEMBL6335979 | 0.62 | SLC6A3 (0.43) | SLC6A2SLC6A4 | |
| SCHEMBL6335455 | 0.62 | TACR1 (0.55) | — | |
| Hydrochloric Acid SCHEMBL6541504 | 0.62 | TACR1 (0.56) | — | |
| SCHEMBL3147349 | 0.61 | SLC6A2 (0.73) | SLC6A2SLC6A4PGRADORA3ADORA2B | |
| SCHEMBL3132109 | 0.61 | SLC6A2 (0.73) | SLC6A2SLC6A4PGRADORA3ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889010-A | PSYCHOLOGICAL DISORDERS; UROGENITAL DISORDERS; COGNITION ACTIVATORS; NERVOUS SYSTEM DISORDERS; VISION DEFECTS; CONGESTIVE HEART FAILURE; DRUG ABRUSE; PARKINSON'S DISEASE;ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | PFIZER INC. (US) | 1999-03-30 | — | — | US | disclosed |
| US-5883094-A | Benzimidazolone derivatives with central dopaminergic activity | PFIZER INC. (US) | 1999-03-16 | — | — | US | disclosed |