Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846869 | 0.88 | NOTUM (0.50) | HSD17B10RAB9ATSHRCYP11B1CYP11B2 | |
| SCHEMBL846566 | 0.86 | HSD17B10 (0.44) | HSD17B10RAB9ATSHRLMNAPOLB | |
| SCHEMBL847037 | 0.85 | TRPV1 (0.56) | RAB9ANPC1KDM4ETRPV1 | |
| SCHEMBL846528 | 0.85 | KDR (0.48) | HSD17B10RAB9ALMNAPOLBNPC1 | |
| SCHEMBL846407 | 0.84 | NPC1 (0.47) | HSD17B10RAB9ATSHRLMNAPOLB | |
| SCHEMBL846954 | 0.83 | TRPV1 (0.45) | HSD17B10RAB9ATSHRLMNAPOLB | |
| SCHEMBL846565 | 0.82 | SMN1; SMN2 (0.47) | HSD17B10RAB9ATSHRLMNAPOLB | |
| SCHEMBL847501 | 0.81 | KDM4E (0.48) | HSD17B10RAB9ATSHRLMNAPOLB | |
| SCHEMBL846419 | 0.80 | ACHE (0.47) | HSD17B10RAB9ANPC1KDM4ESMN1; SMN2 | |
| SCHEMBL846445 | 0.78 | KDM4E (0.48) | HSD17B10RAB9ALMNANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |