Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KAT7 | O95251 | 1/20 | 0.39 |
| ▸ | KAT6B | Q8WYB5 | 1/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8477556 | 0.88 | PTGS2 (0.45) | TP53PTGS2MAPTPTGS1SLC40A1 | |
| SCHEMBL8475638 | 0.86 | TSHR (0.43) | MAPTBRD4BRD2BRD3 | |
| SCHEMBL8473983 | 0.82 | HSD11B1 (0.43) | TP53MAPT | |
| SCHEMBL8475707 | 0.82 | TSHR (0.42) | ALDH1A1KAT6A | |
| SCHEMBL8473864 | 0.82 | PTGS1 (0.42) | PTGS2MAPTHTR6PTGS1SLC40A1 | |
| SCHEMBL8479643 | 0.81 | TSHR (0.46) | SLC40A1HPGDALDH1A1 | |
| SCHEMBL8481482 | 0.79 | TSHR (0.45) | MAPTALDH1A1LMNA | |
| SCHEMBL8478773 | 0.78 | MCL1 (0.46) | HPGDALDH1A1 | |
| SCHEMBL8473763 | 0.78 | EDNRB (0.41) | SLC40A1HPGDBRD4ALDH1A1 | |
| SCHEMBL8478641 | 0.78 | PTGS2 (0.44) | PTGS2HTR6PTGS1SLC40A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |