Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.31 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891460 | 0.91 | MAPT (0.34) | ALDH1A1KMT2AMAPTMEN1L3MBTL1 | |
| SCHEMBL8764436 | 0.85 | GRM2 (0.38) | ALDH1A1MAPTCA12CA1CA2 | |
| SCHEMBL8891587 | 0.85 | MEN1 (0.36) | ALDH1A1KMT2AMAPTMEN1POLB | |
| SCHEMBL8892415 | 0.85 | PPARG (0.34) | ALDH1A1KMT2AMAPTMEN1GRM2 | |
| SCHEMBL8763799 | 0.84 | GRM2 (0.49) | ALDH1A1KMT2AMEN1L3MBTL1CA12 | |
| SCHEMBL8764066 | 0.84 | GRM2 (0.49) | ALDH1A1KMT2AMEN1L3MBTL1CA12 | |
| SCHEMBL8764713 | 0.75 | ALDH1A1 (0.33) | MAPK8MAPK9ALDH1A1GRM2GRM3 | |
| SCHEMBL8907681 | 0.66 | ALDH1A1 (0.41) | ALDH1A1KMT2AMEN1L3MBTL1CA12 | |
| SCHEMBL8762579 | 0.66 | GRM2 (0.63) | ALDH1A1POLBGRM2GRM3 | |
| SCHEMBL8891838 | 0.66 | GRM2 (0.63) | ALDH1A1POLBGRM2GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916920-A | CONTROLLING NEUROTRANSMITTER RECPETORS; NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0774455-A1 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1997-05-21 | — | — | EP | disclosed |