SCHEMBL8892415

SCHEMBL8892415

CCOC(=O)C1C2CC(Cc3ccc(F)cc3)C(C#N)(C(=O)CN)C21

nearest known ligand 0.36

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.34
MAPT P10636 2/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
SLC6A3 Q01959 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 2/20 0.33
RECQL P46063 1/20 0.33
GRM2 Q14416 1/20 0.33
GRM3 Q14832 1/20 0.33
DPP4 P27487 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8891587 0.90 MEN1 (0.36) MAPTMEN1KMT2AALDH1A1GRM2
SCHEMBL8764436 0.89 GRM2 (0.38) MAPTSLC6A3KDM4EALDH1A1GRM2
SCHEMBL8763799 0.87 GRM2 (0.49) MEN1KMT2AKDM4EALDH1A1GRM2
SCHEMBL8764066 0.87 GRM2 (0.49) MEN1KMT2AKDM4EALDH1A1GRM2
SCHEMBL8474292 0.85 MAPK8 (0.33) MAPTMEN1KMT2AALDH1A1GRM2
SCHEMBL20731925 0.73 GRM2 (0.42) PPARGMAPTMEN1KMT2ASLC6A3
SCHEMBL19508460 0.73 GRM2 (0.42) PPARGMAPTMEN1KMT2ASLC6A3
SCHEMBL20730984 0.73 GRM2 (0.42) PPARGMAPTMEN1KMT2ASLC6A3
SCHEMBL20731962 0.73 GRM2 (0.42) PPARGMAPTMEN1KMT2ASLC6A3
SCHEMBL8763881 0.65 MEN1 (0.32) MEN1KMT2AGRM2GRM3DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997017950-A1 SHOULDER PROSTHESIS ELI LILLY AND COMPANY (US) 1997-05-22 WO disclosed