Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8471438 | 0.85 | PTGS1 (0.54) | PTGS1PTGS2KDM4EMEN1ALDH1A1 | |
| SCHEMBL8172578 | 0.84 | SLC9A1 (0.50) | — | |
| SCHEMBL8474684 | 0.83 | PTGS1 (0.45) | PTGS1PTGS2KDM4EMEN1ALDH1A1 | |
| SCHEMBL8832380 | 0.80 | KDM4E (0.45) | KDM4EMEN1ALDH1A1GAAMAPK1 | |
| SCHEMBL8207485 | 0.79 | ALDH1A1 (0.57) | KDM4EMEN1ALDH1A1GAAMAPK1 | |
| SCHEMBL8185434 | 0.77 | SLC9A1 (0.52) | KDM4EMEN1ALDH1A1GAAMAPK1 | |
| SCHEMBL8183089 | 0.75 | SMN1; SMN2 (0.47) | KDM4EMEN1ALDH1A1GAAMAPK1 | |
| SCHEMBL8170154 | 0.74 | SMN1; SMN2 (0.46) | KDM4EMEN1ALDH1A1GAAMAPK1 | |
| SCHEMBL8179861 | 0.74 | SLC9A1 (0.56) | — | |
| SCHEMBL8180285 | 0.73 | SLC9A1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5856344-A | CARDIOVASCULAR DISORDERS; ANTIARRHYTHMIA AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; STOCK | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-01-05 | — | — | US | claimed |
| US-5856344-A | CARDIOVASCULAR DISORDERS; ANTIARRHYTHMIA AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; STOCK | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-01-05 | — | — | US | disclosed |
| EP-0774459-A1 | Sulfonylamino-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent as well as medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-21 | — | — | EP | disclosed |