Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.49 |
| ▸ | EDNRB | P24530 | 7/20 | 0.46 |
| ▸ | EDNRA | P25101 | 7/20 | 0.46 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MLYCD | O95822 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.41 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | OXTR | P30559 | 2/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8479988 | 0.88 | EDNRA (0.55) | EDNRBEDNRAPTGS2 | |
| SCHEMBL8481520 | 0.87 | EDNRA (0.50) | HSD11B1EDNRBEDNRA | |
| SCHEMBL8476607 | 0.86 | EDNRA (0.53) | HSD11B1EDNRBEDNRA | |
| SCHEMBL8478606 | 0.85 | EDNRA (0.59) | HSD11B1EDNRBEDNRAP2RY1 | |
| SCHEMBL8473239 | 0.79 | EDNRA (0.52) | EDNRBEDNRAPTGS2 | |
| SCHEMBL9065130 | 0.76 | EDNRA (0.69) | EDNRBEDNRA | |
| SCHEMBL7850015 | 0.76 | EDNRA (0.69) | EDNRBEDNRA | |
| SCHEMBL8523604 | 0.75 | EDNRA (0.51) | EDNRBEDNRA | |
| SCHEMBL8477061 | 0.75 | EDNRA (0.50) | HSD11B1EDNRBEDNRA | |
| SCHEMBL30844541 | 0.74 | EDNRA (0.68) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |