Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC8 | Q09428 | 11/20 | 0.41 |
| ▸ | KCNJ11 | Q14654 | 11/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8475714 | 0.92 | ABCC8 (0.40) | ABCC8KCNJ11 | |
| SCHEMBL8476120 | 0.83 | ABCC8 (0.40) | ABCC8KCNJ11 | |
| SCHEMBL8473093 | 0.80 | ABCC8 (0.44) | ABCC8KCNJ11 | |
| SCHEMBL8478004 | 0.76 | ABCC8 (0.40) | ABCC8KCNJ11 | |
| SCHEMBL8476298 | 0.74 | ABCC8 (0.39) | ABCC8KCNJ11 | |
| SCHEMBL8715828 | 0.71 | MAPT (0.30) | — | |
| SCHEMBL7077604 | 0.71 | ABCC8 (0.44) | ABCC8KCNJ11GRIA1GRIA2GRIA3 | |
| SCHEMBL8475635 | 0.70 | ALDH1A1 (0.31) | — | |
| SCHEMBL7570919 | 0.68 | ABCC8 (0.32) | ABCC8KCNJ11 | |
| SCHEMBL7564894 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889002-A | CENTRAL NERVOUS SYSTEM DISORDERS; CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS; GASTROINTESTINAL DISORDERS; ENDOCRINAL DISEASES | NOVO NORDISK A/S (DK) | 1999-03-30 | — | — | US | disclosed |
| CN-1208417-A | Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use | NOVO NORDISK AS (DK) | 1999-02-17 | — | — | CN | disclosed |