SCHEMBL8478328

SCHEMBL8478328

CSC(SC)=C1Oc2cc(Cl)c(CC(=O)CC(=O)O)cc2O1

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PGK1 P00558 1/20 0.35
SLC22A12 Q96S37 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7469245 0.79 SLC22A12 (0.44) PGK1SLC22A12
SCHEMBL29142092 0.66 P2RX7 (0.40) PGK1
SCHEMBL4576468 0.66 SLC22A12 (0.50) SLC22A12
SCHEMBL11311719 0.64 ALDH1A1 (0.50)
SCHEMBL7468904 0.64 SLC22A12 (0.42) SLC22A12
SCHEMBL8477318 0.64 RAB9A (0.45) SLC22A12
SCHEMBL31037386 0.63 CYP1A2 (0.38) PGK1SLC22A12
SCHEMBL22685832 0.63 CYP1A2 (0.38) PGK1SLC22A12
SCHEMBL11066945 0.62 TSHR (0.42) SLC22A12
SCHEMBL18301791 0.61 SLC22A12 (0.43) SLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5942622-A NOVEL COMPOUNDS FOR TREATING ILLNESS RESULTING FROM ABNORMAL STIMULATION OF ENDOTHELIAL RECEPTORS; FOR EXAMPLE: 4-((6-CHLORO-1,3-BENZODIOXOL-5-YL)METHYL)-1-(CYCLOHEXYLMETHYL) -3-(2-PYRIDINYL)-1H-PYRAZOLE-5-CARBOXYLATE HOECHST MARION ROUSSEL (FR) 1999-08-24 US disclosed