Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.53 |
| ▸ | GPR132 | Q9UNW8 | 12/20 | 0.50 |
| ▸ | PTAFR | P25105 | 2/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.48 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.45 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8480926 | 0.96 | EPHX1 (0.51) | EPHX1GPR132PTAFRPRMT5WDR77 | |
| SCHEMBL8477406 | 0.89 | GPR132 (0.50) | EPHX1GPR132PTAFRPRMT5WDR77 | |
| SCHEMBL8553957 | 0.89 | GPR132 (0.50) | EPHX1GPR132PTAFRPRMT5WDR77 | |
| Oxalic Acid SCHEMBL8476733 | 0.87 | MEN1 (0.46) | EPHX1GPR132PTAFRMEN1KMT2A | |
| Oxalic Acid SCHEMBL8483076 | 0.87 | MEN1 (0.46) | EPHX1GPR132PTAFRMEN1KMT2A | |
| Oxalic Acid SCHEMBL8476688 | 0.85 | MMP12 (0.55) | EPHX1GPR132PTAFRMEN1KMT2A | |
| SCHEMBL8481421 | 0.85 | MEN1 (0.52) | GPR132PTAFRMEN1KMT2A | |
| SCHEMBL8109540 | 0.85 | MEN1 (0.52) | GPR132PTAFRMEN1KMT2A | |
| SCHEMBL8479732 | 0.85 | MEN1 (0.52) | GPR132PTAFRMEN1KMT2A | |
| SCHEMBL6949036 | 0.85 | MEN1 (0.53) | GPR132MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977105-A | Compounds | ASTRA PHARMAEUTICALS LTD. (GB) | 1999-11-02 | — | — | US | disclosed |
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |