Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | CCR3 | P51677 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8484461 | 0.98 | NPSR1 (0.39) | NPSR1POLBCARM1PRMT6KMT2A | |
| SCHEMBL8665883 | 0.95 | NPSR1 (0.37) | NPSR1POLBCARM1PRMT6KMT2A | |
| SCHEMBL8666099 | 0.93 | NPSR1 (0.36) | NPSR1POLBCARM1PRMT6KMT2A | |
| SCHEMBL8501239 | 0.92 | NPSR1 (0.33) | NPSR1POLBCARM1PRMT6KMT2A | |
| SCHEMBL8501052 | 0.90 | NPSR1 (0.33) | NPSR1POLBGAA | |
| SCHEMBL8483689 | 0.89 | NPSR1 (0.38) | NPSR1POLBCARM1PRMT6KMT2A | |
| SCHEMBL8713186 | 0.89 | DRD2 (0.36) | KMT2AMCHR1MEN1 | |
| SCHEMBL8717987 | 0.88 | CCR3 (0.44) | KMT2AMEN1CCR3SLC6A12 | |
| SCHEMBL8648481 | 0.88 | CCR3 (0.39) | MCHR1CCR3SIGMAR1 | |
| SCHEMBL8483744 | 0.87 | CCR3 (0.44) | NPSR1POLBKMT2AMCHR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883099-A | TREATMENT OF ATHERSCLEROSIS, PANCREATITIS OBESITY OR HYPERGLYCEMIA | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-16 | — | — | US | disclosed |
| US-H1729-H | Method for preparing compounds employing solid phase synthesis and novel linker-resin | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-05 | — | — | US | disclosed |
| US-5739135-A | PREVENTING OR TREATING ATHEROSCLEROSIS, PANCREATITIS SECONDARY TO HYPERTRIGLYCERIDEMIA, HYPERGLYCEMIA, OBESITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-04-14 | — | — | US | disclosed |