Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8485600 | 0.82 | MAOB (0.41) | MAOBMAOAFFAR1JAK2JAK3 | |
| SCHEMBL8486942 | 0.81 | LTB4R2 (0.35) | MAOBMAOAALOX5PTGESFFAR1 | |
| SCHEMBL8910135 | 0.73 | PTPN1 (0.32) | S1PR1 | |
| SCHEMBL8482791 | 0.73 | HRH3 (0.34) | S1PR1 | |
| SCHEMBL27370060 | 0.70 | FFAR1 (0.42) | MAOBMAOAALOX5PTGESFFAR1 | |
| SCHEMBL1601470 | 0.70 | S1PR1 (0.45) | S1PR1 | |
| SCHEMBL8487461 | 0.68 | MAOB (0.40) | MAOBMAOA | |
| SCHEMBL8487248 | 0.68 | LTB4R2 (0.34) | MAOBMAOAS1PR1FAAHACHE | |
| SCHEMBL7440252 | 0.68 | MAOB (0.46) | MAOBMAOAFFAR1 | |
| SCHEMBL7437915 | 0.68 | MAOB (0.42) | MAOBMAOAALOX5PTGESFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955487-A | TREATING HIGH BLOOD PRESSURE, CARDIAC INSUFFICIENCY, GLAUCOMA | CIBA-GEIGY CORPORATION (US) | 1999-09-21 | — | — | US | disclosed |
| US-5620998-A | CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-04-15 | — | — | US | disclosed |
| US-5506240-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |