Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 2/20 | 0.54 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.54 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.54 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.54 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.53 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.53 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8646342 | 0.89 | ABCC9 (0.57) | ABCC9ABCC8KCNJ11KCNJ8GAA | |
| SCHEMBL8846776 | 0.78 | HSD11B1 (0.57) | ABCC9ABCC8KCNJ11KCNJ8TSHR | |
| SCHEMBL8846852 | 0.76 | ABCC9 (0.52) | ABCC9ABCC8KCNJ11KCNJ8TSHR | |
| SCHEMBL3556996 | 0.75 | LMNA (0.68) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL3555800 | 0.75 | LMNA (0.68) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL3551978 | 0.75 | LMNA (0.68) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL24962669 | 0.73 | GCK (0.65) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL8490608 | 0.72 | ABCC9 (0.53) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL24962668 | 0.72 | GCK (0.64) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL11959848 | 0.71 | LMNA (0.76) | ABCC9ABCC8KCNJ11KCNJ8PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999062873-A1 | BENZENESULPHONAMIDE DERIVATIVES AS PYRUVATE DEHYDROGENASE ACTIVATORS | ASTRAZENECA AB (SE) | 1999-12-09 | — | — | WO | claimed |
| EP-0625516-B1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | claimed |
| US-5693639-A | TREATING URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1997-12-02 | — | — | US | claimed |
| EP-0625516-A1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LIMITED (GB) | 1994-11-23 | — | — | EP | claimed |
| WO-1999062873-A1 | BENZENESULPHONAMIDE DERIVATIVES AS PYRUVATE DEHYDROGENASE ACTIVATORS | ASTRAZENECA AB (SE) | 1999-12-09 | — | — | WO | disclosed |
| EP-0625516-B1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5693639-A | TREATING URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1997-12-02 | — | — | US | disclosed |
| US-5510386-A | ADMINISTERING TO RELAX SMOOTH MUSCLE OF THE BLADDER | ZENECA LIMITED (GB) | 1996-04-23 | — | — | US | disclosed |
| EP-0625516-A1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LIMITED (GB) | 1994-11-23 | — | — | EP | disclosed |