Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.57 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.57 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.57 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8486232 | 0.89 | ABCC9 (0.54) | ABCC9ABCC8KCNJ11KCNJ8SMN1; SMN2 | |
| SCHEMBL9347018 | 0.74 | POLB (0.63) | ABCC9ABCC8KCNJ11KCNJ8POLB | |
| SCHEMBL15904229 | 0.74 | POLB (0.67) | POLBL3MBTL1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL12793245 | 0.73 | POLB (0.88) | POLBL3MBTL1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL8611581 | 0.73 | ABCC9 (0.57) | ABCC9ABCC8KCNJ11KCNJ8POLB | |
| SCHEMBL8524297 | 0.73 | ABCC9 (0.57) | ABCC9ABCC8KCNJ11KCNJ8POLB | |
| SCHEMBL5803751 | 0.72 | POLB (0.69) | POLBL3MBTL1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL8846776 | 0.72 | HSD11B1 (0.57) | ABCC9ABCC8KCNJ11KCNJ8KMT2A | |
| SCHEMBL8489832 | 0.72 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8EPHX2 | |
| SCHEMBL24295449 | 0.71 | EPHX2 (0.75) | ABCC9ABCC8KCNJ11KCNJ8POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625516-B1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | claimed |
| US-5693639-A | TREATING URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1997-12-02 | — | — | US | claimed |
| US-5510386-A | ADMINISTERING TO RELAX SMOOTH MUSCLE OF THE BLADDER | ZENECA LIMITED (GB) | 1996-04-23 | — | — | US | claimed |
| EP-0625516-A1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LIMITED (GB) | 1994-11-23 | — | — | EP | claimed |
| EP-0625516-B1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5693639-A | TREATING URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1997-12-02 | — | — | US | disclosed |
| US-5510386-A | ADMINISTERING TO RELAX SMOOTH MUSCLE OF THE BLADDER | ZENECA LIMITED (GB) | 1996-04-23 | — | — | US | disclosed |
| EP-0625516-A1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LIMITED (GB) | 1994-11-23 | — | — | EP | disclosed |