SCHEMBL8488305

SCHEMBL8488305

Oc1ccc(C(c2ccccc2)(C(F)(F)F)C(F)(F)F)cc1

nearest known ligand 0.82

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 9/20 0.82
ESR2 Q92731 8/20 0.82
ALDH1A1 P00352 2/20 0.56
CYP3A4 P08684 2/20 0.56
KIF11 P52732 2/20 0.46
TSHR P16473 2/20 0.44
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
GLA P06280 1/20 0.43
CA3 P07451 1/20 0.43
CA4 P22748 1/20 0.43
CA9 Q16790 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
CA14 Q9ULX7 1/20 0.43
MMP3 P08254 1/20 0.42
BCL2L1 Q07817 1/20 0.42
LMNA P02545 1/20 0.41
TYR P14679 1/20 0.41
AR P10275 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenol SCHEMBL8427030 0.95 ESR1 (0.82) ESR1ESR2ALDH1A1CYP3A4KIF11
SCHEMBL21027 0.91 ESR1 (1.00) ESR1ESR2ALDH1A1CYP3A4KIF11
SCHEMBL4560440 0.91 ESR1 (1.00) ESR1ESR2ALDH1A1CYP3A4KIF11
SCHEMBL3686864 0.91 ESR1 (1.00) ESR1ESR2ALDH1A1CYP3A4KIF11
SCHEMBL8064676 0.90 ESR1 (0.72) ESR1ESR2ALDH1A1CYP3A4KIF11
SCHEMBL30625966 0.88 ESR1 (0.95) ESR1ESR2ALDH1A1CYP3A4KIF11
Potassium SCHEMBL30701764 0.88 ESR1 (0.95) ESR1ESR2ALDH1A1CYP3A4KIF11
SCHEMBL28280787 0.87 ESR1 (0.75) ESR1ESR2ALDH1A1CYP3A4KIF11
SCHEMBL612731 0.85 ALDH1A1 (0.58) ESR1ESR2ALDH1A1KIF11TSHR
SCHEMBL10906373 0.84 ESR1 (0.86) ESR1ESR2ALDH1A1CYP3A4KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11072679-B2 Polyurethanes prepared from oligomeric polyol compositions and polyisocyanates PRESIDIUM USA, INC (US) 2021-07-27 US disclosed
US-20190055345-A1 Polyurethanes Prepared from Oligomeric Polyol Compositions and Polyisocyanates PRESIDIUM INNOVATIONS, LLC 2019-02-21 US disclosed
EP-2094764-B1 TRANSPARENT AND FLAME RETARDANT POLYSULFONE COMPOSITIONS SOLVAY ADVANCED POLYMERS LLC (US) 2010-09-22 EP disclosed
US-20080286629-A1 CHEMICALLY CROSS LINKED IONOMER MEMBRANE POLYFUEL, INC. (US) 2008-11-20 US disclosed
WO-2008059004-A1 TRANSPARENT AND FLAME RETARDANT POLYSULFONE COMPOSITIONS SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2008-05-22 WO disclosed
US-5889012-A INSECTICIDE, ACARICIDES, FUNGICIDES HOECHST-SCHERING AGREVO GMBH (DE) 1999-03-30 US disclosed
EP-0787128-A1 SUBSTITUTED CYCLOALKYLAMINO AND CYCLOALKOXY HETEROCYCLES, PROCESS FOR PREPARING THE SAME AND THEIR USE AS PESTICIDES Hoechst Schering AgrEvo GmbH (DE) 1997-08-06 EP disclosed
WO-1996011913-A1 SUBSTITUTED CYCLOALKYLAMINO AND CYCLOALKOXY HETEROCYCLES, PROCESS FOR PREPARING THE SAME AND THEIR USE AS PESTICIDES HOECHST SCHERING AGREVO GMBH (DE) 1996-04-25 WO disclosed