SCHEMBL3686864

SCHEMBL3686864

Oc1ccc(C(c2ccc(O)cc2)(C(F)(F)F)C(F)(F)F)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 11/20 1.00
ESR2 Q92731 11/20 1.00
KIF11 P52732 1/20 0.54
CYP3A4 P08684 3/20 0.48
LMNA P02545 2/20 0.48
TYR P14679 2/20 0.48
HPGD P15428 2/20 0.48
HSD17B10 Q99714 2/20 0.48
AR P10275 1/20 0.48
TSHR P16473 1/20 0.48
SLC6A2 P23975 1/20 0.48
SLC6A4 P31645 1/20 0.48
HTR6 P50406 1/20 0.48
ESRRG P62508 1/20 0.48
SLC6A3 Q01959 1/20 0.48
ALDH1A1 P00352 2/20 0.44
KDM4E B2RXH2 1/20 0.44
MEN1 O00255 1/20 0.44
NPC1 O15118 1/20 0.44
CA12 O43570 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4560440 1.00 ESR1 (1.00) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL21027 1.00 ESR1 (1.00) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL30625966 0.97 ESR1 (0.95) ESR1ESR2KIF11CYP3A4LMNA
Potassium SCHEMBL30701764 0.97 ESR1 (0.95) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL7935379 0.93 ESR1 (0.86) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL10906373 0.93 ESR1 (0.86) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL6059770 0.93 ESR1 (0.86) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL6059489 0.93 ESR1 (0.86) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL8488305 0.91 ESR1 (0.82) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL28278720 0.91 ESR1 (0.82) ESR1ESR2KIF11CYP3A4LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170260389-A1 POLYESTER CO-PHOSPHONATES FRX POLYMERS, INC. 2017-09-14 US claimed
EP-2867272-A1 POLYESTER CO-PHOSPHONATES FRX Polymers, Inc. (US) 2015-05-06 EP claimed
WO-2014005136-A1 POLYESTER CO-PHOSPHONATES FRX POLYMERS, INC. (US) 2014-01-03 WO claimed
US-20140000751-A1 POLYESTER CO-PHOSPHONATES DOSKOCIL MANUFACTURING COMPANY, INC. 2014-01-02 US claimed
EP-3365168-B1 LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES SCHNELLER LLC (US) 2021-06-30 EP disclosed
US-20200338873-A1 LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES SCHNELLER LLC (US) 2020-10-29 US disclosed
EP-3365168-A1 LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES Schneller, LLC (US) 2018-08-29 EP disclosed
US-20170260389-A1 POLYESTER CO-PHOSPHONATES FRX POLYMERS, INC. 2017-09-14 US disclosed
US-9695278-B2 Polyester co-phosphonates FRX POLYMERS, INC. (US) 2017-07-04 US disclosed
WO-2017070276-A1 LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES SCHNELLER LLC (US) 2017-04-27 WO disclosed
US-20170113445-A1 LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES SCHNELLER LLC 2017-04-27 US disclosed
US-9527984-B2 Polyphosphonate and copolyphosphonate additive mixtures FRX POLYMERS, INC. (US) 2016-12-27 US disclosed
EP-2697309-A2 POLYPHOSPHONATE AND COPOLYPHOSPHONATE ADDITIVE MIXTURES FRX Polymers, Inc. (US) 2014-02-19 EP disclosed
WO-2014005136-A1 POLYESTER CO-PHOSPHONATES FRX POLYMERS, INC. (US) 2014-01-03 WO disclosed
US-20140000751-A1 POLYESTER CO-PHOSPHONATES DOSKOCIL MANUFACTURING COMPANY, INC. 2014-01-02 US disclosed
EP-1979395-B1 METHOD FOR THE PRODUCTION OF BLOCK COPOLYCARBONATE/PHOSPHONATES AND COMPOSITIONS THEREFROM FRX POLYMERS INC (US) 2013-05-01 EP disclosed
US-20120264844-A1 POLYPHOSPHONATE AND COPOLYPHOSPHONATE ADDITIVE MIXTURES FRX POLYMERS, INC. (US) 2012-10-18 US disclosed
WO-2012142596-A2 POLYPHOSPHONATE AND COPOLYPHOSPHONATE ADDITIVE MIXTURES FRX POLYMERS, INC. (US) 2012-10-18 WO disclosed
US-7838604-B2 Method for the production of block copolycarbonate/phosphonates and compositions therefrom FRX POLYMERS, INC. (US) 2010-11-23 US disclosed
US-20100130703-A1 METHOD FOR THE PRODUCTION OF BLOCK COPOLYCARBONATE/PHOSPHONATES AND COMPOSITIONS THEREFROM FRX POLYMERS, INC. 2010-05-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100130703-A1 METHOD FOR THE PRODUCTION OF BLOCK COPOLYCARBONATE/PHOSPHONATES AND COMPOSITIONS THEREFROM PFAS, MGAM, FGB ESR1 4790/4885ESR2 4780/4885KIF11 288/4885
US-20170260389-A1 POLYESTER CO-PHOSPHONATES PHOSPHO1, PNKP, PHYKPL ESR1 2108/4885ESR2 3634/4885KIF11 1176/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.