Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 8/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 6/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8482137 | 0.95 | AGTR1 (0.43) | AGTR1LTB4R2PTGDR2PKMAGTR2 | |
| SCHEMBL8912327 | 0.95 | AGTR1 (0.41) | AGTR1LTB4R2PTGDR2PKMAGTR2 | |
| SCHEMBL8483446 | 0.95 | AGTR1 (0.43) | AGTR1LTB4R2PTGDR2PKMAGTR2 | |
| SCHEMBL8912222 | 0.94 | OPRM1 (0.35) | AGTR1LTB4R2PTGDR2AGTR2 | |
| SCHEMBL8489272 | 0.90 | MEN1 (0.33) | AGTR1AGTR2FFAR4 | |
| SCHEMBL8486859 | 0.89 | LTB4R2 (0.34) | AGTR1LTB4R2PTGDR2PKM | |
| SCHEMBL8486836 | 0.89 | AGTR1 (0.33) | AGTR1AGTR2 | |
| SCHEMBL8910698 | 0.89 | LTB4R2 (0.35) | AGTR1LTB4R2AGTR2FFAR4 | |
| SCHEMBL9080460 | 0.88 | LTB4R2 (0.34) | AGTR1LTB4R2PTGDR2PKM | |
| SCHEMBL8811670 | 0.88 | AGTR1 (0.36) | AGTR1LTB4R2PTGDR2PKMAGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955487-A | TREATING HIGH BLOOD PRESSURE, CARDIAC INSUFFICIENCY, GLAUCOMA | CIBA-GEIGY CORPORATION (US) | 1999-09-21 | — | — | US | disclosed |
| US-5620998-A | CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-04-15 | — | — | US | disclosed |
| US-5506240-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |