SCHEMBL8488395

SCHEMBL8488395

NCC(=O)N1CCN(C=O)CC1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RECQL P46063 1/20 0.45
SIGMAR1 Q99720 1/20 0.44
TSHR P16473 2/20 0.43
RAB9A P51151 1/20 0.41
LMNA P02545 2/20 0.40
CPN1 P15169 1/20 0.40
CPB2 Q96IY4 1/20 0.40
TFPI2 P48307 1/20 0.39
AKR1C1 Q04828 1/20 0.39
ALDH1A1 P00352 4/20 0.38
HSD17B10 Q99714 2/20 0.38
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38
USP2 O75604 1/20 0.38
CYP3A4 P08684 1/20 0.38
HPGD P15428 1/20 0.38
KMT2A Q03164 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
MAPT P10636 1/20 0.37
THRB P10828 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19387563 0.85 SIGMAR1 (0.46) RECQLSIGMAR1TSHRRAB9ALMNA
SCHEMBL22814152 0.85
SCHEMBL1860296 0.85 ALDH1A1 (0.48) SIGMAR1TSHRLMNACPN1CPB2
SCHEMBL9530974 0.80 BLM (0.50) RECQLTSHRRAB9ALMNAALDH1A1
SCHEMBL8488391 0.80 RECQL (0.44) RECQLTSHRRAB9ALMNATFPI2
SCHEMBL6417613 0.80 RECQL (0.44) RECQLTSHRRAB9ALMNATFPI2
SCHEMBL3657369 0.77 ALDH1A1 (0.61) SIGMAR1CPN1CPB2ALDH1A1MEN1
SCHEMBL9532280 0.77 L3MBTL1 (0.46) RECQLTSHRRAB9ALMNAALDH1A1
SCHEMBL18712308 0.77 ALDH1A1 (0.43) RECQLTSHRRAB9ALMNATFPI2
SCHEMBL9674149 0.77 LMNA (0.72) RECQLTSHRRAB9ALMNATFPI2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5977102-A INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES OR EPIDERMAL GROWTH FACTOR; ANTITUMOR,-CARCINOGENIC, -METASTASIS,-PROLIFERATION AGENTS AND -INFLAMMATORY AGENTS; PSORIASIS; ANGIOGENESIS INHIBITORS; IMMUNOLOGY; DR. KARL THOMAE GMBH (DE) 1999-11-02 US claimed
US-9771345-B2 Coferons and methods of making and using them CORNELL UNIVERSITY (US) 2017-09-26 US disclosed
US-5977102-A INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES OR EPIDERMAL GROWTH FACTOR; ANTITUMOR,-CARCINOGENIC, -METASTASIS,-PROLIFERATION AGENTS AND -INFLAMMATORY AGENTS; PSORIASIS; ANGIOGENESIS INHIBITORS; IMMUNOLOGY; DR. KARL THOMAE GMBH (DE) 1999-11-02 US disclosed