Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8486496 | 0.82 | ALDH1A1 (0.50) | ALDH1A1LMNAMEN1KMT2AMAPK1 | |
| SCHEMBL8485836 | 0.78 | ALDH1A1 (0.55) | ALDH1A1LMNAMEN1KMT2AMAPK1 | |
| SCHEMBL8483139 | 0.75 | KDM4E (0.56) | ALDH1A1LMNAMEN1KMT2AMAPK1 | |
| SCHEMBL8795501 | 0.75 | KDM4E (0.53) | ALDH1A1MEN1KMT2AMAPK1PKM | |
| SCHEMBL23016797 | 0.71 | ALDH1A1 (0.60) | ALDH1A1LMNAMEN1KMT2AMAPK1 | |
| SCHEMBL12085541 | 0.69 | ALDH1A1 (0.55) | ALDH1A1LMNAMEN1KMT2AMAPK1 | |
| SCHEMBL11888598 | 0.68 | CYP1A2 (0.74) | ALDH1A1LMNAMEN1KMT2AMAPK1 | |
| SCHEMBL8485189 | 0.67 | TP53 (0.48) | ALDH1A1KMT2AMAPK1SMN1; SMN2CYP1A2 | |
| SCHEMBL8795385 | 0.66 | POLB (0.61) | ALDH1A1MEN1KMT2APKMCYP3A4 | |
| SCHEMBL8485554 | 0.65 | QPCT (0.63) | ALDH1A1MEN1KMT2ASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0792873-A1 | N-(Phenoxyalkyl) carboxamides and their use as antiarrhythmic agents | American Cyanamid Company (US) | 1997-09-03 | — | — | EP | claimed |
| US-5877196-A | N- 4-(imidazolyl or pyrazolyl)phenyl(oxy, sulfinyl, sulfenyl or sulfonyl)alkyl!carboxamides, sulfonamides or phosphoramides having antiarrhythmic properties | AMERICAN CYANAMID COMPANY (US) | 1999-03-02 | — | — | US | disclosed |
| EP-0792873-A1 | N-(Phenoxyalkyl) carboxamides and their use as antiarrhythmic agents | American Cyanamid Company (US) | 1997-09-03 | — | — | EP | disclosed |