Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15811557 | 0.83 | TDP1 (0.41) | LMNAHPGDCA1CA2ERN1 | |
| SCHEMBL10430712 | 0.82 | POLB (0.42) | LMNAHPGDERN1POLBCYP19A1 | |
| SCHEMBL10430946 | 0.82 | POLB (0.42) | LMNAHPGDERN1POLBCYP19A1 | |
| SCHEMBL30433465 | 0.81 | LMNA (0.58) | LMNAHPGDERN1POLBALDH1A1 | |
| SCHEMBL7822146 | 0.81 | KDM4E (0.47) | LMNAHPGDPOLBALDH1A1TDP1 | |
| SCHEMBL24986410 | 0.77 | POLB (0.44) | LMNAHPGDPOLBCYP19A1NQO2 | |
| SCHEMBL3360383 | 0.77 | POLB (0.50) | LMNAHPGDPOLBCYP19A1NQO2 | |
| SCHEMBL2232816 | 0.77 | ALDH1A1 (0.45) | LMNAHPGDERN1CYP19A1NQO2 | |
| SCHEMBL10430779 | 0.77 | POLB (0.43) | POLBCYP19A1NQO2TARBP2KMT2A | |
| SCHEMBL10620315 | 0.76 | POLB (0.39) | LMNAHPGDPOLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-62084079-A | — | — | None | — | — | JP | disclosed |
| JP-62096486-A | — | — | None | — | — | JP | disclosed |
| JP-62061974-A | — | — | None | — | — | JP | disclosed |
| US-10227356-B2 | Compounds, compositions and methods for inhibiting CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2019-03-12 | — | — | US | disclosed |
| US-20160304533-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2016-10-20 | — | — | US | disclosed |
| US-5889018-A | ADMINISTERING TO THE PATIENT SUFFERING FROM ANXIETY A 1-STYRYLISOQUINOLINE COMPOUND AS AN ANXIOLYTIC AGENT | EGIS GYOGYSZERGYAR RT. (HU) | 1999-03-30 | — | — | US | disclosed |
| EP-0680953-A1 | 1-[Styryl]- and 1-[2'-(heteroaryl)-ethenyl]-isoquinoline derivatives, a process for preparing them as well as medicaments containing them and the use of them | EGIS GYOGYSZERGYAR RT. (HU) | 1995-11-08 | — | — | EP | disclosed |
| EP-0404694-A2 | 4-hydroxy-8-methoxy-2-methyl-6, 7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline, and process for preparing the same | MITSUBISHI KASEI CORPORATION (JP) | 1990-12-27 | — | — | EP | disclosed |
| US-4963684-A | OXIDATION AMINO GROUP OF A TETRAHYDROISOQUINOLINE COMPOUND; HYDROLYSIS | MITSUBISHI KASEI CORPORATION (JP) | 1990-10-16 | — | — | US | disclosed |
| EP-0387156-A2 | A process for preparing cotarnine | MITSUBISHI KASEI CORPORATION (JP) | 1990-09-12 | — | — | EP | disclosed |
| EP-0285267-A2 | Pyridine derivatives for treatment and prevention of liver damage, and their preparation | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1988-10-05 | — | — | EP | disclosed |
| US-4769480-A | Benzylamine derivative | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1988-09-06 | — | — | US | disclosed |
| US-4760145-A | Certain 6,7-methylene dioxydihydro or tetrahydro-isoquinoline derivatives | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1988-07-26 | — | — | US | disclosed |
| EP-0232199-A2 | Aromatic benzamido compounds, process for their preparation and their use in human or veterinary medicine as well as in cosmetics | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1987-08-12 | — | — | EP | disclosed |
| JP-S6296486-A | SEPARATION OF BENZALDEHYDE DERIVATIVE | MITSUBISHI CHEM IND LTD | 1987-05-02 | — | — | JP | disclosed |
| JP-S6284079-A | PRODUCTION OF 2,3-METHYLENEDIOXYANISOLE | MITSUBISHI CHEM IND LTD | 1987-04-17 | — | — | JP | disclosed |
| EP-0216696-A2 | Process for preparing cotarnine | MITSUBISHI KASEI CORPORATION (JP) | 1987-04-01 | — | — | EP | disclosed |
| JP-S6261974-A | METHOD OF PURIFYING 2-METHOXY-3,4-METHYLENEDIOXYBENZALDEHYDE | MITSUBISHI CHEM IND LTD | 1987-03-18 | — | — | JP | disclosed |
| EP-0214905-A2 | Tetrahydroisoquinoline derivatives | MITSUBISHI KASEI CORPORATION (JP) | 1987-03-18 | — | — | EP | disclosed |
| EP-0214051-A2 | Benzylamine derivative | MITSUBISHI KASEI CORPORATION (JP) | 1987-03-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227356-B2 | Compounds, compositions and methods for inhibiting CNKSR1 | CNKSR1, CAMKK1, CNR1 | LMNA 1703/4885HPGD 3849/4885CA1 4118/4885 |
| US-20160304533-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR INHIBITING CNKSR1 | CNKSR1, CAMKK1, CNR1 | LMNA 1703/4885HPGD 3849/4885CA1 4118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.