Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.32 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8488097 | 0.75 | DPP4 (0.37) | DPP4DPP7SIGMAR1GNAI3GNAO1 | |
| SCHEMBL6225365 | 0.72 | GNAI3 (0.35) | DPP4DPP7SIGMAR1GNAI3GNAO1 | |
| SCHEMBL8531483 | 0.71 | SIGMAR1 (0.34) | DPP4DPP7SIGMAR1GNAI3GNAO1 | |
| SCHEMBL10935772 | 0.68 | HTR7 (0.45) | DPP4DPP7MEN1KMT2ACYP2D6 | |
| SCHEMBL10289656 | 0.66 | DPP4 (0.50) | DPP4DPP7SIGMAR1MEN1KMT2A | |
| SCHEMBL10289644 | 0.66 | DPP4 (0.50) | DPP4DPP7SIGMAR1MEN1KMT2A | |
| SCHEMBL27862405 | 0.66 | GNAI3 (0.47) | MEN1KMT2AGNAI3GNAO1GNAI1 | |
| SCHEMBL27800903 | 0.64 | MEN1 (0.38) | DPP4DPP7SIGMAR1MEN1KMT2A | |
| SCHEMBL6495579 | 0.64 | LMNA (0.33) | GNAI3GNAO1GNAI1 | |
| SCHEMBL19748690 | 0.63 | CA1 (0.39) | SIGMAR1GNAI3GNAO1GNAI1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869488-A | Piperazino derivatives as neurokinin antagonists | SCHERING CORPORATION (US) | 1999-02-09 | — | — | US | disclosed |