Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 2/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8489042 | 0.80 | GAA (0.40) | SMN1; SMN2NPC1LMNAMAPTALDH1A1 | |
| SCHEMBL8489148 | 0.78 | GAA (0.52) | SMN1; SMN2NPC1LMNAMAPTALDH1A1 | |
| SCHEMBL5734450 | 0.69 | POLB (0.41) | SMN1; SMN2NPC1LMNAMAPTALDH1A1 | |
| Bromide SCHEMBL5734269 | 0.68 | POLB (0.41) | SMN1; SMN2NPC1LMNAMAPTALDH1A1 | |
| SCHEMBL7427899 | 0.68 | POLB (0.41) | SMN1; SMN2NPC1LMNAMAPTALDH1A1 | |
| SCHEMBL8485814 | 0.66 | GAA (0.43) | SMN1; SMN2NPC1LMNAMAPTALDH1A1 | |
| SCHEMBL6579962 | 0.66 | L3MBTL1 (0.39) | ALDH1A1NAMPT | |
| SCHEMBL833262 | 0.62 | IDO1 (0.34) | LMNAMAPTALDH1A1POLB | |
| SCHEMBL6584578 | 0.62 | KDM4E (0.42) | NPC1LMNAMAPTALDH1A1POLB | |
| SCHEMBL8485856 | 0.62 | GAA (0.43) | SMN1; SMN2NPC1LMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955463-A | ANTITUMOR, ANTIINFLAMMATORY, AND ANTIARTHRITIC AGENTS | ZENECA LIMITED (GB) | 1999-09-21 | — | — | US | disclosed |