Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 7/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582320 | 0.86 | KDM4E (0.40) | L3MBTL1KDM4EALOX15TSHRTDP1 | |
| SCHEMBL6584578 | 0.78 | KDM4E (0.42) | KDM4EALDH1A1 | |
| SCHEMBL6584027 | 0.73 | NAMPT (0.55) | NAMPT | |
| SCHEMBL8489148 | 0.70 | GAA (0.52) | KDM4EHDAC6HDAC8ALDH1A1TNF | |
| SCHEMBL8489042 | 0.69 | GAA (0.40) | KDM4EHDAC6HDAC8ALDH1A1TNF | |
| SCHEMBL8489146 | 0.66 | SMN1; SMN2 (0.31) | NAMPTALDH1A1 | |
| SCHEMBL9389151 | 0.64 | KDM4E (0.42) | L3MBTL1KDM4EALOX15TDP1ALDH1A1 | |
| SCHEMBL6582992 | 0.63 | ALDH1A1 (0.41) | KDM4EALDH1A1 | |
| SCHEMBL336664 | 0.62 | CYP4F2 (0.49) | L3MBTL1KDM4EALOX15TSHRTDP1 | |
| SCHEMBL30038312 | 0.62 | RORC (0.33) | KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155012-B1 | ANTI-CANCER DIHYDROQUINAZOLINE DERIVATIVES | CANCER REC TECH LTD (GB) | 2004-04-14 | — | — | EP | disclosed |
| US-6699861-B1 | ANTI-CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2004-03-02 | — | — | US | disclosed |
| EP-1155012-A1 | ANTI-CANCER DIHYDROQUINAZOLINE DERIVATIVES | Cancer Research Ventures Limited (GB) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050417-A1 | ANTI-CANCER DIHYDROQUINAZOLINE DERIVATIVES | CANCER RESEARCH VENTURES LIMITED (GB) | 2000-08-31 | — | — | WO | disclosed |