SCHEMBL8489175

SCHEMBL8489175

C#CCc1cc([N+](=O)[O-])ccc1OC(=O)O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.42
PTGDR2 Q9Y5Y4 1/20 0.42
ALDH1A1 P00352 5/20 0.41
MAPT P10636 4/20 0.39
HPGD P15428 2/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
GAA P10253 1/20 0.38
CRHBP P24387 1/20 0.38
HTT P42858 1/20 0.38
CRHR2 Q13324 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
CYP3A4 P08684 2/20 0.38
POLB P06746 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38
TDP1 Q9NUW8 2/20 0.38
ALOX15 P16050 1/20 0.38
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8489171 1.00 CYP1A2 (0.42) CYP1A2PTGDR2ALDH1A1MAPTHPGD
SCHEMBL8489170 0.90 CYP1A2 (0.40) CYP1A2PTGDR2ALDH1A1MAPTHPGD
SCHEMBL32662599 0.85 CYP1A2 (0.46) CYP1A2PTGDR2ALDH1A1MAPTHPGD
SCHEMBL28102381 0.84 ALDH1A1 (0.46) CYP1A2PTGDR2ALDH1A1MAPTHPGD
SCHEMBL27958906 0.83 HSPB1 (0.43) ALDH1A1MAPTHPGDMEN1KMT2A
SCHEMBL2993627 0.82 CYP1A2 (0.44) CYP1A2PTGDR2ALDH1A1MAPTHPGD
SCHEMBL2995979 0.82 CYP1A2 (0.44) CYP1A2PTGDR2ALDH1A1MAPTHPGD
SCHEMBL2993625 0.82 CYP1A2 (0.44) CYP1A2PTGDR2ALDH1A1MAPTHPGD
SCHEMBL2995973 0.82 CYP1A2 (0.44) CYP1A2PTGDR2ALDH1A1MAPTHPGD
SCHEMBL27573003 0.81 TSHR (0.46) CYP1A2PTGDR2ALDH1A1MAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999032481-A1 MUSCARINIC AGENTS AND USE THEREOF TO TREAT GLAUCOMA, MYOPIA AND VARIOUS OTHER CONDITIONS ALCON LABORATORIES, INC. (US) 1999-07-01 WO disclosed