Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 16/20 | 0.74 |
| ▸ | ABCC8 | Q09428 | 16/20 | 0.74 |
| ▸ | KCNJ11 | Q14654 | 16/20 | 0.74 |
| ▸ | KCNJ8 | Q15842 | 16/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | PDK1 | Q15118 | 6/20 | 0.71 |
| ▸ | PDK2 | Q15119 | 6/20 | 0.71 |
| ▸ | PDK3 | Q15120 | 6/20 | 0.71 |
| ▸ | PDK4 | Q16654 | 6/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2128828 | 0.85 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL6359557 | 0.84 | PDK1 (1.00) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL28050469 | 0.84 | PDK1 (1.00) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL5748675 | 0.82 | PTGES2 (0.74) | PDK1PDK2PDK3PDK4ABCB11 | |
| SCHEMBL6570953 | 0.81 | ABCC9 (0.64) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL6568189 | 0.80 | ABCB11 (0.69) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL6568185 | 0.80 | ABCB11 (0.69) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL8488331 | 0.80 | ABCC9 (0.76) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL6570941 | 0.80 | PTGES2 (0.65) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL27553234 | 0.80 | PTGES2 (0.65) | ABCC9ABCC8KCNJ11KCNJ8MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999062873-A1 | BENZENESULPHONAMIDE DERIVATIVES AS PYRUVATE DEHYDROGENASE ACTIVATORS | ASTRAZENECA AB (SE) | 1999-12-09 | — | — | WO | claimed |
| EP-0625516-B1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | claimed |
| WO-1999062873-A1 | BENZENESULPHONAMIDE DERIVATIVES AS PYRUVATE DEHYDROGENASE ACTIVATORS | ASTRAZENECA AB (SE) | 1999-12-09 | — | — | WO | disclosed |
| US-5693639-A | TREATING URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1997-12-02 | — | — | US | disclosed |
| US-5510386-A | ADMINISTERING TO RELAX SMOOTH MUSCLE OF THE BLADDER | ZENECA LIMITED (GB) | 1996-04-23 | — | — | US | disclosed |