Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | CTSE | P14091 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.34 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9572737 | 0.86 | SMN1; SMN2 (0.39) | CCR5CYP2D6CYP1A2PKMSMN1; SMN2 | |
| SCHEMBL9572874 | 0.83 | POLB (0.40) | CYP2D6CYP1A2PKMSMN1; SMN2NPSR1 | |
| SCHEMBL10526741 | 0.82 | ESR1 (0.40) | SMN1; SMN2LMNAFFAR1TSHRCYP2C9 | |
| SCHEMBL9572983 | 0.82 | CCR5 (0.40) | CCR5CYP2D6CYP1A2PKMSMN1; SMN2 | |
| SCHEMBL9572673 | 0.80 | CCR5 (0.38) | CCR5CYP2D6CYP1A2PKMSMN1; SMN2 | |
| SCHEMBL1683176 | 0.78 | CA12 (0.42) | CYP2D6CYP1A2PKMSMN1; SMN2NPSR1 | |
| SCHEMBL6871261 | 0.78 | LMNA (0.46) | CCR5CYP2D6CYP1A2PKMSMN1; SMN2 | |
| SCHEMBL5895589 | 0.78 | LMNA (0.46) | CCR5CYP2D6CYP1A2PKMSMN1; SMN2 | |
| SCHEMBL424239 | 0.77 | TAAR1 (0.47) | TAAR1FFAR1 | |
| SCHEMBL4476581 | 0.76 | LMNA (0.45) | CCR5CYP2D6CYP1A2PKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999018082-A1 | NOVEL SUBSTITUTED PYRIDAZINONES | BASF AKTIENGESELLSCHAFT (DE) | 1999-04-15 | — | — | WO | disclosed |
| EP-0562832-A1 | Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use | SANKYO COMPANY LIMITED (JP) | 1993-09-29 | — | — | EP | disclosed |
| US-4591458-A | ENZYME INHIBITORS; HYPOTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-05-27 | — | — | US | disclosed |
| US-4548932-A | ANGIOTENSIN INHIBITOR, HYPOTENSIVE AGENT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1985-10-22 | — | — | US | disclosed |