Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | DPP4 | P27487 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8492339 | 0.91 | NPC1 (0.39) | NPC1GPR6MAPTDPP4LMNA | |
| SCHEMBL8762846 | 0.91 | LMNA (0.42) | NPC1GPR6MAPTDPP4LMNA | |
| SCHEMBL8494679 | 0.89 | NR1H4 (0.40) | NPC1GPR6MAPTLMNAGAA | |
| SCHEMBL6594174 | 0.86 | NPC1 (0.40) | NPC1GPR6MAPTDPP4LMNA | |
| SCHEMBL8492287 | 0.85 | DPP4 (0.36) | NPC1GPR6MAPTDPP4GAA | |
| SCHEMBL8489321 | 0.85 | GLP1R (0.39) | NPC1GPR6MAPTNR1H4MEN1 | |
| SCHEMBL6595018 | 0.83 | NPC1 (0.38) | NPC1GPR6MAPTDPP4LMNA | |
| SCHEMBL8492665 | 0.82 | NPC1 (0.38) | NPC1GPR6MAPTDPP4LMNA | |
| SCHEMBL8493354 | 0.81 | FTO (0.39) | NPC1GPR6MAPTLMNARAB9A | |
| SCHEMBL8762890 | 0.80 | SMURF2 (0.39) | DPP4DPP7NR1H4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1040940-C | Composition containing 4-benzoyl isoxazole derivative and application thereof | RHONE POULENE AGRICULTURE LTD (GB) | 1998-12-02 | — | — | CN | claimed |
| US-5656573-A | Herbicidal 4-substituted isoxazoles | RHONE-POULENC AGRICULTURE LTD. (GB) | 1997-08-12 | — | — | US | claimed |
| EP-0487357-B1 | 4 Benzoyl isoxazole derivatives | RHONE POULENC AGRICULTURE (GB) | 1997-07-02 | — | — | EP | claimed |
| CN-1061596-A | 4-Benzoylisoxazole Derivatives | RHONE POULENC AGRICULTURE (GB) | 1992-06-03 | — | — | CN | claimed |
| EP-0487357-A1 | 4 Benzoyl isoxazole derivatives | RHONE-POULENC AGRICULTURE LTD. (GB) | 1992-05-27 | — | — | EP | claimed |
| CN-1093537-C | Process for preparing composition contg. 4 -benzoyl-iso-oxazole derivs. | PHONE POULENC AGRICULTURE LTD (GB) | 2002-10-30 | — | — | CN | disclosed |
| US-5859283-A | TERTIARY-BUTYL 3-CYCLOALKYL-3-OXOPROPIONATE | RHONE-POULENC AGRICULTURE LIMITED (GB) | 1999-01-12 | — | — | US | disclosed |
| CN-1040940-C | Composition containing 4-benzoyl isoxazole derivative and application thereof | RHONE POULENE AGRICULTURE LTD (GB) | 1998-12-02 | — | — | CN | disclosed |
| CN-1183411-A | Process for preparing composition contg. 4 -benzoyl-iso-oxazole derivs. | RHONE POULENC AGRICULTURE (GB) | 1998-06-03 | — | — | CN | disclosed |
| US-5747424-A | HEATING AN AROMATIC DIKETONE WITH A SALT OF HYDROXYLAMINE IN A SOLVENT | RHONE-POULENC AGRICULTURE LTD. (GB) | 1998-05-05 | — | — | US | disclosed |
| US-5656573-A | Herbicidal 4-substituted isoxazoles | RHONE-POULENC AGRICULTURE LTD. (GB) | 1997-08-12 | — | — | US | disclosed |
| US-5650533-A | Intermediates to herbicidal 4-substituted isoxazoles | RHONE-POULENC AGRICULTURE LTD. (GB) | 1997-07-22 | — | — | US | disclosed |
| EP-0487357-B1 | 4 Benzoyl isoxazole derivatives | RHONE POULENC AGRICULTURE (GB) | 1997-07-02 | — | — | EP | disclosed |
| CN-1061596-A | 4-Benzoylisoxazole Derivatives | RHONE POULENC AGRICULTURE (GB) | 1992-06-03 | — | — | CN | disclosed |
| EP-0487357-A1 | 4 Benzoyl isoxazole derivatives | RHONE-POULENC AGRICULTURE LTD. (GB) | 1992-05-27 | — | — | EP | disclosed |