Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.50 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5402685 | 0.88 | TBXAS1 (0.49) | HRH1HTR2AGRM2GRM3TBXAS1 | |
| SCHEMBL27593431 | 0.88 | SIGMAR1 (0.49) | HRH1HTR2AGRM2GRM3TBXAS1 | |
| SCHEMBL5692956 | 0.87 | TBXAS1 (0.63) | HRH1HTR2AGRM2GRM3TBXAS1 | |
| SCHEMBL8494351 | 0.86 | MTNR1A (0.52) | HRH1HTR2AGRM2GRM3TBXAS1 | |
| SCHEMBL4219820 | 0.85 | HRH1 (0.57) | HRH1HTR2AGRM2GRM3TBXAS1 | |
| Hydrochloric Acid SCHEMBL2861647 | 0.85 | TBXAS1 (0.61) | HRH1HTR2AGRM2GRM3TBXAS1 | |
| SCHEMBL7011219 | 0.84 | ASAH1 (0.52) | TBXAS1SIGMAR1 | |
| SCHEMBL31108377 | 0.84 | ASAH1 (0.52) | TBXAS1SIGMAR1 | |
| SCHEMBL3943859 | 0.84 | MTNR1A (0.47) | HRH1HTR2AGRM2GRM3TBXAS1 | |
| SCHEMBL8551678 | 0.83 | HTR2A (0.47) | HRH1HTR2AGRM2GRM3TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-B1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1999-12-08 | — | — | EP | disclosed |
| US-5717109-A | CARBOXYCYCLOPROPYL GLYCINE DERIVATIVES; USEFUL FOR TREATMENT OF ACUTE OR CHRONIC NEURODEGENERATIVE CONDITIONS, AND AS ANTIPSYCHOTIC, ANTICONVULSANT, ANALGESIC, ANXIOLYTIC, ANTIDEPRESSANT AND ANTI-EMETIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |