Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.47 |
| ▸ | HRH1 | P35367 | 4/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20484039 | 0.84 | CHRNB2 (0.49) | HTR2AHRH1CHRNB2CHRNB4CHRNA4 | |
| SCHEMBL8494372 | 0.83 | HRH1 (0.54) | HTR2AHRH1SIGMAR1MTNR1AMTNR1B | |
| SCHEMBL27593431 | 0.77 | SIGMAR1 (0.49) | HTR2AHRH1SIGMAR1MTNR1AMTNR1B | |
| SCHEMBL8494351 | 0.76 | MTNR1A (0.52) | HTR2AHRH1MTNR1AMTNR1BTBXAS1 | |
| SCHEMBL5402685 | 0.74 | TBXAS1 (0.49) | HTR2AHRH1MTNR1AMTNR1BTBXAS1 | |
| SCHEMBL8551676 | 0.74 | GRIN1 (0.46) | CHRNB2CHRNB4CHRNA4CHRNA3 | |
| SCHEMBL31108377 | 0.73 | ASAH1 (0.52) | SIGMAR1TBXAS1 | |
| SCHEMBL7011219 | 0.73 | ASAH1 (0.52) | SIGMAR1TBXAS1 | |
| SCHEMBL3943859 | 0.73 | MTNR1A (0.47) | HTR2AHRH1SIGMAR1MTNR1AMTNR1B | |
| SCHEMBL5692956 | 0.73 | TBXAS1 (0.63) | HTR2AHRH1MTNR1AMTNR1BTBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0827502-A1 | METHADONE DERIVATIVES AND PROTEIN AND POLYPEPTIDE METHADONE DERIVATIVE CONJUGATES AND LABELS | BIOSITE DIAGNOSTICS INC. (US) | 1998-03-11 | — | — | EP | disclosed |
| WO-1996031496-A1 | METHADONE DERIVATIVES AND PROTEIN AND POLYPEPTIDE METHADONE DERIVATIVE CONJUGATES AND LABELS | BIOSITE DIAGNOSTICS, INCORPORATED (US) | 1996-10-10 | — | — | WO | disclosed |