Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 4/20 | 0.41 |
| ▸ | ERCC1 | P07992 | 3/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 3/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6765934 | 0.90 | KMT2A (0.44) | EPHX2SIGMAR1KMT2AANO1ERCC1 | |
| SCHEMBL6764649 | 0.88 | KMT2A (0.46) | SIGMAR1KMT2AANO1ERCC1ERCC4 | |
| SCHEMBL6766386 | 0.85 | SIGMAR1 (0.44) | EPHX2SIGMAR1KMT2AANO1ERCC1 | |
| SCHEMBL13385942 | 0.85 | ALDH1A1 (0.48) | EPHX2KMT2AANO1 | |
| SCHEMBL6766382 | 0.84 | KMT2A (0.41) | EPHX2SIGMAR1KMT2AANO1ERCC1 | |
| SCHEMBL10164756 | 0.83 | KMT2A (0.42) | EPHX2SIGMAR1KMT2AANO1P2RX7 | |
| SCHEMBL13938980 | 0.83 | ANO1 (0.43) | KMT2AANO1ERCC1ERCC4P2RX7 | |
| SCHEMBL16357932 | 0.76 | ANO1 (0.49) | KMT2AANO1 | |
| SCHEMBL6766304 | 0.74 | SHMT1 (0.48) | EPHX2SIGMAR1KMT2AERCC1ERCC4 | |
| SCHEMBL16302161 | 0.73 | ANO1 (0.45) | KMT2AANO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433940-B9 | SPIROIMIDAZOLONE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2015-10-28 | — | — | EP | disclosed |
| EP-2433940-B1 | SPIROIMIDAZOLONE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2014-09-24 | — | — | EP | disclosed |
| EP-2433940-A1 | SPIROIMIDAZOLONE DERIVATIVE | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-03-28 | — | — | EP | disclosed |