Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8492114 | 0.84 | NPC1 (0.50) | RAB9AKMT2AMEN1FFAR2NPC1 | |
| SCHEMBL8491551 | 0.84 | PTK2 (0.51) | RAB9AKMT2AMEN1MAPTNPC1 | |
| SCHEMBL8493247 | 0.81 | CYP11B2 (0.58) | RAB9AKMT2AMEN1POLBMAPT | |
| SCHEMBL6498338 | 0.77 | ALDH1A1 (0.38) | KMT2AMEN1POLBMAPTGAA | |
| SCHEMBL8493684 | 0.77 | RAB9A (0.53) | RAB9AKDM4EKMT2AMEN1MAPT | |
| SCHEMBL6496159 | 0.76 | NPC1 (0.53) | RAB9AKDM4EKMT2AMEN1POLB | |
| SCHEMBL6486115 | 0.76 | KCNMA1 (0.50) | RAB9AKDM4EKMT2AMEN1POLB | |
| SCHEMBL5375281 | 0.75 | KDM4E (0.72) | RAB9AKDM4EKMT2AMEN1POLB | |
| SCHEMBL8491870 | 0.75 | NPC1 (0.53) | RAB9AKMT2AMEN1FFAR2NPC1 | |
| SCHEMBL8495767 | 0.74 | PTK2 (0.51) | RAB9AKMT2AMEN1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999011621-A2 | THIOUREA FOR INCREASING HDL-CHOLESTEROL LEVELS, WHICH ARE USEFUL AS ANTI-ATHEROSCLEROTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-11 | — | — | WO | claimed |
| WO-1999011621-A2 | THIOUREA FOR INCREASING HDL-CHOLESTEROL LEVELS, WHICH ARE USEFUL AS ANTI-ATHEROSCLEROTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-11 | — | — | WO | disclosed |