SCHEMBL8495472

SCHEMBL8495472

O=C(c1ccccc1)c1cc(Br)c(Br)c(Br)c1Br

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.51
POLB P06746 1/20 0.51
AKR1C3 P42330 2/20 0.48
ALDH1A1 P00352 1/20 0.48
ATM Q13315 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
GAA P10253 2/20 0.46
CYP2C8 P10632 1/20 0.46
CYP2C9 P11712 1/20 0.46
KDM4E B2RXH2 1/20 0.46
MEN1 O00255 1/20 0.46
USP2 O75604 1/20 0.46
KMT2A Q03164 1/20 0.46
KEAP1 Q14145 1/20 0.46
NFE2L2 Q16236 1/20 0.46
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
HPGD P15428 1/20 0.44
CYP2C19 P33261 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7931235 0.82 ALDH1A1 (0.50) MAPTPOLBAKR1C3ALDH1A1ATM
SCHEMBL27534988 0.81 MAPT (0.45) MAPTPOLBAKR1C3ALDH1A1ATM
SCHEMBL15792959 0.80 MAPT (0.56) MAPTPOLBAKR1C3ALDH1A1ATM
SCHEMBL28387359 0.79 LMNA (0.42) MAPTPOLBALDH1A1TDP1GAA
SCHEMBL28585473 0.78 SNCA (0.35) MAPTPOLBALDH1A1TDP1KDM4E
SCHEMBL30285373 0.78 SNCA (0.35) MAPTPOLBALDH1A1TDP1KDM4E
SCHEMBL29255916 0.78 PTPN1 (0.61) MAPTPOLBAKR1C3ALDH1A1ATM
SCHEMBL1560518 0.78 MEN1 (0.51) MAPTPOLBAKR1C3ALDH1A1ATM
SCHEMBL501331 0.76 GAA (0.53) MAPTPOLBAKR1C3ALDH1A1ATM
SCHEMBL11342058 0.76 BCL2 (0.58) MAPTPOLBAKR1C3ALDH1A1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104327003-A FLUORINE DERIVATIVES FOR ORGANIC ELECTROLUMINESCENCE DEVICES MERCK PATENT GMBH 2015-02-04 CN disclosed
CN-103228759-A Material for organic electroluminescent device FRAUNHOFER GES FORSCHUNG 2013-07-31 CN disclosed
WO-1999038833-A1 PROCESS FOR THE HALOGENATION OF ALDEHYDES AND KETONES BROMINE COMPOUNDS LTD. (IL) 1999-08-05 WO disclosed
EP-0293115-B1 Melt-stable poly(arylene thiotherketone) and production process thereof KUREHA CHEMICAL IND CO LTD (JP) 1997-09-17 EP disclosed
US-5378772-A Copolymerization of poly(arylene thioetherketoneketones) KUREHA KAGAKU KOGYO K.K. (JP) 1995-01-03 US disclosed
US-5378771-A Sulfiding dihalobenzene and bis(halobenzoyl)benzene in two steps to copolymerize poly(arylene thioetherketoneketones) KUREHA KAGAKU KOGYO K.K.K. (JP) 1995-01-03 US disclosed
US-5248743-A Polythioethers KUREHA KAGAKU KOGYO K.K. (JP) 1993-09-28 US disclosed
US-5153264-A Heating dihalo aromatic compound and alkali metal sulfide, mixing with dihalo aromatic carbonyl compound; organic amide and water solvent KUREHA KAGAKU KOGYO K.K. (JP) 1992-10-06 US disclosed
US-5153279-A Heat resistance, melt processability KUREHA KAGAKU KOGYO K.K. (JP) 1992-10-06 US disclosed
US-5153278-A Heat resistance, workability; materials handling; molding materials; films KUREHA KAGAKU KOGYO K.K. (JP) 1992-10-06 US disclosed
US-5120808-A Melt processability, heat resistance polyether ketone polymers KUREHA KAGAKU KOGYO K.K. (JP) 1992-06-09 US disclosed
EP-0435674-A2 High-heat-resistant, crystalline block copolymers and production process thereof KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1991-07-03 EP disclosed
EP-0369620-A2 Poly(arylene thioether)block copolymer and production process thereof KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1990-05-23 EP disclosed
US-4895925-A HEAT RESISTANT MOLDING MATERIAL KUREHA KAGAKU KOGYO K.K. (JP) 1990-01-23 US disclosed
US-4886871-A REACTING ALKALI METAL SULFIDE AND DIHALOGENATED COMPOUNDS KUREHA KAGAKU KOGYO K. K. (JP) 1989-12-12 US disclosed