Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 4/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL7318127 | 0.75 | F2 (0.35) | F2PRSS1F10 | |
| SCHEMBL7311770 | 0.69 | F2 (0.34) | HTTF2PRSS1ALDH1A1GAA | |
| SCHEMBL16253665 | 0.65 | KMO (0.42) | TSHRHTTKMORAB9ALMNA | |
| SCHEMBL7407793 | 0.64 | TSHR (0.36) | TSHRHTTKMOSMN1; SMN2MEN1 | |
| SCHEMBL23409789 | 0.61 | PKM (0.46) | TSHRRAB9AHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL5070898 | 0.60 | ALDH1A1 (0.50) | TSHRHTTMAPTLMNAHPGD | |
| SCHEMBL7322304 | 0.59 | NPC1 (0.55) | F2PRSS1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL11005143 | 0.59 | GSTO1 (0.49) | TSHRHTTRAB9AMAPTLMNA | |
| SCHEMBL12155310 | 0.58 | ALDH1A1 (0.38) | TSHRHTTRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL5490567 | 0.58 | HPGD (0.38) | HTTRAB9ALMNAPOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932606-A | Pyrazinone, pyridinone, piperidine and pyrrolidine thrombin inhibitors | MERCK & CO., INC. (US) | 1999-08-03 | — | — | US | disclosed |