Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 10/20 | 0.55 |
| ▸ | HTR7 | P34969 | 10/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | CFTR | P13569 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8495772 | 0.88 | LMNA (0.61) | LMNAPKMGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL18773975 | 0.81 | LMNA (0.51) | LMNAPKMGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL30377746 | 0.81 | CXCR3 (0.54) | HTR1AHTR7HTR2AHTR6 | |
| SCHEMBL27431297 | 0.79 | POLB (0.65) | PKMHTR1AHTR7GAAALDH1A1 | |
| SCHEMBL23093165 | 0.78 | LMNA (0.55) | LMNAPKMHTR1AHTR7GAA | |
| SCHEMBL4111979 | 0.78 | TDP1 (0.62) | LMNAPKMHTR1AHTR7GAA | |
| SCHEMBL29715382 | 0.78 | LMNA (0.55) | LMNAPKMHTR1AHTR7GAA | |
| SCHEMBL1690525 | 0.78 | LMNA (0.54) | LMNAPKMGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL18970120 | 0.78 | LMNA (0.54) | LMNAPKMGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL12518071 | 0.76 | LMNA (0.61) | LMNAPKMGAAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998047877-A1 | 2-BENZOYL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HEPATIC PRODUCTION OF APOB-100 | GLAXO GROUP LIMITED (GB) | 1998-10-29 | — | — | WO | disclosed |