Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | HBB | P68871 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8499168 | 0.98 | ALDH1A1 (0.35) | ALDH1A1MAPK1SIGMAR1PYCR1NPSR1 | |
| SCHEMBL6587771 | 0.90 | ALDH1A1 (0.31) | ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL8497326 | 0.83 | ALDH1A1 (0.33) | ALDH1A1MAPK1RAPGEF4KMT2A | |
| SCHEMBL5416310 | 0.80 | ALDH1A1 (0.35) | ALDH1A1MAPK1RAPGEF4ALOX15 | |
| Hydrochloric Acid SCHEMBL9445170 | 0.77 | ALDH1A1 (0.41) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11711460 | 0.77 | PYCR1 (0.34) | ALDH1A1MAPK1SIGMAR1PYCR1NPSR1 | |
| Hydrochloric Acid SCHEMBL8948391 | 0.76 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL324210 | 0.76 | ALDH1A1 (0.35) | ALDH1A1MAPK1SIGMAR1PYCR1NPSR1 | |
| SCHEMBL29955874 | 0.76 | ALDH1A1 (0.35) | ALDH1A1MAPK1SIGMAR1PYCR1NPSR1 | |
| SCHEMBL12156965 | 0.75 | TDP1 (0.42) | ALDH1A1NPSR1RAPGEF4KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0599270-B1 | Method of detecting phosphatase | AISIN SEIKI (JP) | 1999-05-12 | — | — | EP | claimed |
| EP-0599270-A2 | Method of detecting phosphatase | AISIN SEIKI KABUSHIKI KAISHA (JP) | 1994-06-01 | — | — | EP | claimed |
| EP-0599270-B1 | Method of detecting phosphatase | AISIN SEIKI (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5480791-A | Method of detecting phosphatase | AISIN SEIKI KABUSHIKI KAISHA (JP) | 1996-01-02 | — | — | US | disclosed |
| EP-0599270-A2 | Method of detecting phosphatase | AISIN SEIKI KABUSHIKI KAISHA (JP) | 1994-06-01 | — | — | EP | disclosed |