Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 3/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3669556 | 0.94 | AGTR2 (0.44) | AGTR2NOTUMMEN1KMT2ATSHR | |
| SCHEMBL8192461 | 0.83 | AGTR2 (0.37) | AGTR2MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL8592475 | 0.83 | NOTUM (0.44) | NOTUMMEN1KMT2ATSHRUSP2 | |
| SCHEMBL8592708 | 0.83 | NOTUM (0.44) | AGTR2NOTUMMEN1KMT2AALDH1A1 | |
| SCHEMBL3447709 | 0.82 | HTR1A (0.50) | NOTUMMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL8493524 | 0.82 | DRD2 (0.43) | MEN1KMT2ATSHRALDH1A1LMNA | |
| SCHEMBL8984626 | 0.82 | NOTUM (0.48) | AGTR2NOTUMMEN1KMT2AALDH1A1 | |
| SCHEMBL8984815 | 0.81 | AR (0.39) | TSHRALDH1A1LMNAMAPTAKR1C3 | |
| SCHEMBL8594519 | 0.80 | KMT2A (0.43) | MEN1KMT2AALDH1A1FAAHMAPK1 | |
| SCHEMBL8984615 | 0.80 | SLC6A9 (0.46) | MEN1KMT2AALDH1A1FAAHSLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655463-B1 | Cyclic hexapeptides having endothelin antagonistic activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-09-01 | — | — | EP | claimed |
| EP-0552417-B1 | Cyclic peptides and use thereof | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-07-07 | — | — | EP | claimed |
| EP-0528312-B1 | Cyclic peptides and use thereof | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-07-16 | — | — | EP | claimed |