Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 5/20 | 0.68 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8499745 | 0.91 | CAPN1 (0.66) | CAPN1AGTR2BCHE | |
| SCHEMBL8499887 | 0.78 | CAPN1 (0.57) | CAPN1AGTR2ACE | |
| SCHEMBL27938420 | 0.74 | SIGMAR1 (0.47) | CAPN1AGTR2ACEBCHE | |
| SCHEMBL8498396 | 0.69 | CAPN1 (0.53) | CAPN1 | |
| SCHEMBL10851383 | 0.68 | PDE4B (0.61) | AGTR2ACE | |
| SCHEMBL8498676 | 0.67 | CAPN1 (0.63) | CAPN1ACE | |
| SCHEMBL29695296 | 0.65 | ACHE (0.63) | — | |
| SCHEMBL15903276 | 0.65 | BCHE (0.65) | BCHE | |
| SCHEMBL23464974 | 0.65 | GRM6 (0.56) | AGTR2ACE | |
| SCHEMBL6488253 | 0.65 | GRM6 (0.56) | AGTR2ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938477-A4 | BENZOTHIAZO AND RELATED HETEROCYCLIC GROUP-CONTAINING CYSTEINE AND SERINE PROTEASE INHIBITORS | CEPHALON INC (US) | 1999-12-29 | — | — | EP | disclosed |
| US-5952328-A | MAY BE USED TO ALLEVIATE, MEDIATE, REDUCE AND/OR PREVENT DISORDERS WHICH ARE ASSOCIATED WITH ABNORMAL AND/OR ABERRANT ACTIVITY OF CYSTEINE PROTEASES AND/OR SERINE PROTEASES | CEPHALON, INC. (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0938477-A1 | BENZOTHIAZO AND RELATED HETEROCYCLIC GROUP-CONTAINING CYSTEINE AND SERINE PROTEASE INHIBITORS | CEPHALON, INC. (US) | 1999-09-01 | — | — | EP | disclosed |
| WO-1998021186-A1 | BENZOTHIAZO AND RELATED HETEROCYCLIC GROUP-CONTAINING CYSTEINE AND SERINE PROTEASE INHIBITORS | CEPHALON, INC. (US) | 1998-05-22 | — | — | WO | disclosed |