Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 11/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 11/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3784355 | 0.79 | SIGMAR1 (0.44) | LMNA | |
| SCHEMBL4212347 | 0.79 | POLB (0.50) | PRMT5WDR77POLB | |
| SCHEMBL1299631 | 0.76 | SIGMAR1 (0.52) | POLB | |
| SCHEMBL5774496 | 0.76 | TSHR (0.41) | POLBLMNAHTT | |
| Hydrochloric Acid SCHEMBL1299136 | 0.75 | SIGMAR1 (0.51) | POLBLMNA | |
| SCHEMBL5656404 | 0.74 | NPC1 (0.43) | POLB | |
| SCHEMBL4391732 | 0.74 | ALDH1A1 (0.51) | POLBHTT | |
| SCHEMBL5750199 | 0.74 | GRIN2D (0.40) | OPRM1LMNAHTT | |
| SCHEMBL5750674 | 0.73 | LTA4H (0.41) | OPRM1 | |
| SCHEMBL938718 | 0.72 | EPHX1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999024022-A2 | ISOQUINOLINE DERIVATIVES FOR TREATING DISORDERS ASSOCIATED WITH 5HT7 RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-20 | — | — | WO | disclosed |