Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.51 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.44 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NMT2 | O60551 | 1/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8500162 | 0.98 | TACR1 (0.50) | TACR1SLC6A4SLC5A1SLC5A2F10 | |
| SCHEMBL13964062 | 0.85 | TAAR1 (0.48) | SLC5A1SLC5A2FFAR1HTR2AHTR2C | |
| SCHEMBL3953274 | 0.84 | NMT2 (0.46) | TACR1SLC6A4F10SLC6A2SLC6A3 | |
| SCHEMBL9285630 | 0.84 | KEAP1 (0.48) | FFAR1ITGB3ITGA2BPOLB | |
| Hydrochloric Acid SCHEMBL1475977 | 0.83 | NMT2 (0.46) | TACR1SLC6A4F10SLC6A2SLC6A3 | |
| SCHEMBL8669485 | 0.81 | ALDH1A1 (0.61) | SLC5A1SLC5A2FFAR1SLC6A2SLC6A3 | |
| SCHEMBL5081412 | 0.78 | KMT2A (0.59) | F10POLB | |
| SCHEMBL24201498 | 0.76 | MEN1 (0.51) | SLC6A4SLC5A1SLC5A2FFAR1SLC6A2 | |
| SCHEMBL9275115 | 0.76 | SLC6A2 (0.43) | TACR1SLC6A4SLC6A2SLC6A3HTR1A | |
| Hydrochloric Acid SCHEMBL1475573 | 0.75 | SLC6A2 (0.42) | TACR1SLC6A4SLC6A2SLC6A3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874445-A | ADMINISTERING A THERAPEUTICAL AMOUNT OF (+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-(2-(4-FLUOREPHENYL) ETHYL)-4-PIPERIDIENEMETHANOL FOR THE TREATMENT OF INTERMITTENT CLAUDICATION | MERRELL PHARMACEUTICAL, INC. (US) | 1999-02-23 | — | — | US | disclosed |
| US-5721249-A | ADMINISTERING TO TREAT ANGINA | MERRELL PHARMACEUTICALS INC. (US) | 1998-02-24 | — | — | US | disclosed |
| US-5700812-A | ANTISPASMODIC AGENT FOR CARDIOVASCULAR DISORDER, ANTISEROTONINE AGENT | MERRELL PHARMACEUTICALS INC. (US) | 1997-12-23 | — | — | US | disclosed |
| US-5700813-A | TREATMENT OF THROMBOTIC ILLNESS | MERRELL PHARMACEUTICALS INC. (US) | 1997-12-23 | — | — | US | disclosed |
| EP-0626968-A4 | — | — | 1995-01-04 | — | — | EP | disclosed |
| EP-0626968-A1 | PIPERIDINYL THIACYCLIC DERIVATIVES | MERRELL PHARMACEUTICALS INC. (US) | 1994-12-07 | — | — | EP | disclosed |