Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 19/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 16/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8497550 | 0.94 | ESR1 (0.49) | ESR1ESR2KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8497867 | 0.93 | ESR1 (0.57) | ESR1ESR2 | |
| SCHEMBL8500225 | 0.93 | ESR1 (0.48) | ESR1ESR2KMT2A | |
| SCHEMBL8501462 | 0.92 | ESR1 (0.47) | ESR1ESR2KMT2AMAPT | |
| SCHEMBL8499330 | 0.92 | ESR1 (0.53) | ESR1ESR2KMT2ARAB9A | |
| SCHEMBL8501028 | 0.90 | ESR1 (0.56) | ESR1ESR2 | |
| SCHEMBL8500471 | 0.88 | ESR1 (0.51) | ESR1ESR2 | |
| SCHEMBL8501206 | 0.88 | MAPT (0.45) | ESR1ESR2KMT2ASMN1; SMN2RECQL | |
| SCHEMBL8498096 | 0.87 | ESR1 (0.48) | ESR1ESR2KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8498071 | 0.86 | ESR1 (0.60) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | claimed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |